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Construction of a plasmid-free l-leucine overproducing Escherichia coli strain through reprogramming of the metabolic flux

BACKGROUND: l-Leucine is a high-value amino acid with promising applications in the medicine and feed industries. However, the complex metabolic network and intracellular redox imbalance in fermentative microbes limit their efficient biosynthesis of l-leucine. RESULTS: In this study, we applied rati...

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Detalles Bibliográficos
Autores principales:	Hao, Yanan, Pan, Xuewei, Li, Guomin, You, Jiajia, Zhang, Hengwei, Yan, Sihan, Xu, Meijuan, Rao, Zhiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541719/ https://www.ncbi.nlm.nih.gov/pubmed/37775757 http://dx.doi.org/10.1186/s13068-023-02397-x

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