Relapse of lupus nephritis induced by nivolumab in an 84-year-old patient with oral cancer: a case report

Various immunity-related adverse events have been reported to be associated with the inhibition of programmed cell death receptor 1. We report a rare case of a relapse of lupus nephritis (LN), involving rapidly progressive glomerulonephritis, which was induced by nivolumab treatment in a patient wit...

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Autores principales: Zhou, Zhou, Zhang, Qiankun, Wang, Xinbin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2023
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541768/
https://www.ncbi.nlm.nih.gov/pubmed/37773731
http://dx.doi.org/10.1177/03000605231202140
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author Zhou, Zhou
Zhang, Qiankun
Wang, Xinbin
author_facet Zhou, Zhou
Zhang, Qiankun
Wang, Xinbin
author_sort Zhou, Zhou
collection PubMed
description Various immunity-related adverse events have been reported to be associated with the inhibition of programmed cell death receptor 1. We report a rare case of a relapse of lupus nephritis (LN), involving rapidly progressive glomerulonephritis, which was induced by nivolumab treatment in a patient with oral cancer. The patient had a history of systemic lupus erythematosus and underwent treatment with steroids, rituximab, and plasmapheresis. However, her renal function did not improve, and she died of multiple organ failure. To our knowledge, this is the first description of severe LN induced by nivolumab.
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spelling pubmed-105417682023-10-02 Relapse of lupus nephritis induced by nivolumab in an 84-year-old patient with oral cancer: a case report Zhou, Zhou Zhang, Qiankun Wang, Xinbin J Int Med Res Case Reports Various immunity-related adverse events have been reported to be associated with the inhibition of programmed cell death receptor 1. We report a rare case of a relapse of lupus nephritis (LN), involving rapidly progressive glomerulonephritis, which was induced by nivolumab treatment in a patient with oral cancer. The patient had a history of systemic lupus erythematosus and underwent treatment with steroids, rituximab, and plasmapheresis. However, her renal function did not improve, and she died of multiple organ failure. To our knowledge, this is the first description of severe LN induced by nivolumab. SAGE Publications 2023-09-29 /pmc/articles/PMC10541768/ /pubmed/37773731 http://dx.doi.org/10.1177/03000605231202140 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by-nc/4.0/Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Reports
Zhou, Zhou
Zhang, Qiankun
Wang, Xinbin
Relapse of lupus nephritis induced by nivolumab in an 84-year-old patient with oral cancer: a case report
title Relapse of lupus nephritis induced by nivolumab in an 84-year-old patient with oral cancer: a case report
title_full Relapse of lupus nephritis induced by nivolumab in an 84-year-old patient with oral cancer: a case report
title_fullStr Relapse of lupus nephritis induced by nivolumab in an 84-year-old patient with oral cancer: a case report
title_full_unstemmed Relapse of lupus nephritis induced by nivolumab in an 84-year-old patient with oral cancer: a case report
title_short Relapse of lupus nephritis induced by nivolumab in an 84-year-old patient with oral cancer: a case report
title_sort relapse of lupus nephritis induced by nivolumab in an 84-year-old patient with oral cancer: a case report
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541768/
https://www.ncbi.nlm.nih.gov/pubmed/37773731
http://dx.doi.org/10.1177/03000605231202140
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AT zhangqiankun relapseoflupusnephritisinducedbynivolumabinan84yearoldpatientwithoralcanceracasereport
AT wangxinbin relapseoflupusnephritisinducedbynivolumabinan84yearoldpatientwithoralcanceracasereport

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