A novel synthesized prodrug of gemcitabine based on oxygen-free radical sensitivity inhibited the growth of lung cancer cells

In the present study, we introduced the H (2)O (2)-sensitive thiazolidinone moiety at the 4th amino group of gemcitabine (GEM) to synthesize a new target compound named GEM-ZZQ, and then we confirmed its chemical structure by nuclear magnetic resonance spectroscopy. We further confirmed that GEM-ZZQ...

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Detalles Bibliográficos
Autores principales: Chai, Xinlu, Meng, Yuting, Ge, Wei, Wang, Juan, Li, Fei, Wang, Xue Jun, Wang, Xuerong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Editorial Department of Journal of Biomedical Research 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541775/
https://www.ncbi.nlm.nih.gov/pubmed/37705111
http://dx.doi.org/10.7555/JBR.37.20230022

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