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HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas
Ionizing radiation is a popular and effective treatment option for glioblastoma (GBM). However, resistance to radiation therapy inevitably occurs during treatment. It is urgent to investigate the mechanisms of radioresistance in GBM and to find ways to improve radiosensitivity. Here, we found that h...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editorial Department of Journal of Biomedical Research
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541777/ https://www.ncbi.nlm.nih.gov/pubmed/37750323 http://dx.doi.org/10.7555/JBR.37.20220234 |
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author | Li, Yanhui Ge, Yuqian Zhao, Mengjie Ding, Fangshu Wang, Xiuxing Shi, Zhumei Ge, Xin Wang, Xiefeng Qian, Xu |
author_facet | Li, Yanhui Ge, Yuqian Zhao, Mengjie Ding, Fangshu Wang, Xiuxing Shi, Zhumei Ge, Xin Wang, Xiefeng Qian, Xu |
author_sort | Li, Yanhui |
collection | PubMed |
description | Ionizing radiation is a popular and effective treatment option for glioblastoma (GBM). However, resistance to radiation therapy inevitably occurs during treatment. It is urgent to investigate the mechanisms of radioresistance in GBM and to find ways to improve radiosensitivity. Here, we found that heat shock protein 90 beta family member 1 (HSP90B1) was significantly upregulated in radioresistant GBM cell lines. More importantly, HSP90B1 promoted the localization of glucose transporter type 1, a key rate-limiting factor of glycolysis, on the plasma membrane, which in turn enhanced glycolytic activity and subsequently tumor growth and radioresistance of GBM cells. These findings imply that targeting HSP90B1 may effectively improve the efficacy of radiotherapy for GBM patients, a potential new approach to the treatment of glioblastoma. |
format | Online Article Text |
id | pubmed-10541777 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Editorial Department of Journal of Biomedical Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-105417772023-10-02 HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas Li, Yanhui Ge, Yuqian Zhao, Mengjie Ding, Fangshu Wang, Xiuxing Shi, Zhumei Ge, Xin Wang, Xiefeng Qian, Xu J Biomed Res Original Article Ionizing radiation is a popular and effective treatment option for glioblastoma (GBM). However, resistance to radiation therapy inevitably occurs during treatment. It is urgent to investigate the mechanisms of radioresistance in GBM and to find ways to improve radiosensitivity. Here, we found that heat shock protein 90 beta family member 1 (HSP90B1) was significantly upregulated in radioresistant GBM cell lines. More importantly, HSP90B1 promoted the localization of glucose transporter type 1, a key rate-limiting factor of glycolysis, on the plasma membrane, which in turn enhanced glycolytic activity and subsequently tumor growth and radioresistance of GBM cells. These findings imply that targeting HSP90B1 may effectively improve the efficacy of radiotherapy for GBM patients, a potential new approach to the treatment of glioblastoma. Editorial Department of Journal of Biomedical Research 2023-09 2023-09-28 /pmc/articles/PMC10541777/ /pubmed/37750323 http://dx.doi.org/10.7555/JBR.37.20220234 Text en Copyright and License information: Journal of Biomedical Research, CAS Springer-Verlag Berlin Heidelberg 2023 https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Original Article Li, Yanhui Ge, Yuqian Zhao, Mengjie Ding, Fangshu Wang, Xiuxing Shi, Zhumei Ge, Xin Wang, Xiefeng Qian, Xu HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas |
title | HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas |
title_full | HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas |
title_fullStr | HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas |
title_full_unstemmed | HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas |
title_short | HSP90B1-mediated plasma membrane localization of GLUT1 promotes radioresistance of glioblastomas |
title_sort | hsp90b1-mediated plasma membrane localization of glut1 promotes radioresistance of glioblastomas |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541777/ https://www.ncbi.nlm.nih.gov/pubmed/37750323 http://dx.doi.org/10.7555/JBR.37.20220234 |
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