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Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention

Dental caries is the most common human disease caused by oral biofilms despite the widespread use of fluoride as the primary anticaries agent. Recently, an FDA-approved iron oxide nanoparticle (ferumoxytol, Fer) has shown to kill and degrade caries-causing biofilms through catalytic activation of hy...

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Autores principales: Huang, Yue, Liu, Yuan, Pandey, Nil Kanatha, Shah, Shrey, Simon-Soro, Aurea, Hsu, Jessica C., Ren, Zhi, Xiang, Zhenting, Kim, Dongyeop, Ito, Tatsuro, Oh, Min Jun, Buckley, Christine, Alawi, Faizan, Li, Yong, Smeets, Paul J. M., Boyer, Sarah, Zhao, Xingchen, Joester, Derk, Zero, Domenick T., Cormode, David P., Koo, Hyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541875/
https://www.ncbi.nlm.nih.gov/pubmed/37773239
http://dx.doi.org/10.1038/s41467-023-41687-8
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author Huang, Yue
Liu, Yuan
Pandey, Nil Kanatha
Shah, Shrey
Simon-Soro, Aurea
Hsu, Jessica C.
Ren, Zhi
Xiang, Zhenting
Kim, Dongyeop
Ito, Tatsuro
Oh, Min Jun
Buckley, Christine
Alawi, Faizan
Li, Yong
Smeets, Paul J. M.
Boyer, Sarah
Zhao, Xingchen
Joester, Derk
Zero, Domenick T.
Cormode, David P.
Koo, Hyun
author_facet Huang, Yue
Liu, Yuan
Pandey, Nil Kanatha
Shah, Shrey
Simon-Soro, Aurea
Hsu, Jessica C.
Ren, Zhi
Xiang, Zhenting
Kim, Dongyeop
Ito, Tatsuro
Oh, Min Jun
Buckley, Christine
Alawi, Faizan
Li, Yong
Smeets, Paul J. M.
Boyer, Sarah
Zhao, Xingchen
Joester, Derk
Zero, Domenick T.
Cormode, David P.
Koo, Hyun
author_sort Huang, Yue
collection PubMed
description Dental caries is the most common human disease caused by oral biofilms despite the widespread use of fluoride as the primary anticaries agent. Recently, an FDA-approved iron oxide nanoparticle (ferumoxytol, Fer) has shown to kill and degrade caries-causing biofilms through catalytic activation of hydrogen peroxide. However, Fer cannot interfere with enamel acid demineralization. Here, we show notable synergy when Fer is combined with stannous fluoride (SnF(2)), markedly inhibiting both biofilm accumulation and enamel damage more effectively than either alone. Unexpectedly, we discover that the stability of SnF(2) is enhanced when mixed with Fer in aqueous solutions while increasing catalytic activity of Fer without any additives. Notably, Fer in combination with SnF(2) is exceptionally effective in controlling dental caries in vivo, even at four times lower concentrations, without adverse effects on host tissues or oral microbiome. Our results reveal a potent therapeutic synergism using approved agents while providing facile SnF(2) stabilization, to prevent a widespread oral disease with reduced fluoride exposure.
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spelling pubmed-105418752023-10-02 Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention Huang, Yue Liu, Yuan Pandey, Nil Kanatha Shah, Shrey Simon-Soro, Aurea Hsu, Jessica C. Ren, Zhi Xiang, Zhenting Kim, Dongyeop Ito, Tatsuro Oh, Min Jun Buckley, Christine Alawi, Faizan Li, Yong Smeets, Paul J. M. Boyer, Sarah Zhao, Xingchen Joester, Derk Zero, Domenick T. Cormode, David P. Koo, Hyun Nat Commun Article Dental caries is the most common human disease caused by oral biofilms despite the widespread use of fluoride as the primary anticaries agent. Recently, an FDA-approved iron oxide nanoparticle (ferumoxytol, Fer) has shown to kill and degrade caries-causing biofilms through catalytic activation of hydrogen peroxide. However, Fer cannot interfere with enamel acid demineralization. Here, we show notable synergy when Fer is combined with stannous fluoride (SnF(2)), markedly inhibiting both biofilm accumulation and enamel damage more effectively than either alone. Unexpectedly, we discover that the stability of SnF(2) is enhanced when mixed with Fer in aqueous solutions while increasing catalytic activity of Fer without any additives. Notably, Fer in combination with SnF(2) is exceptionally effective in controlling dental caries in vivo, even at four times lower concentrations, without adverse effects on host tissues or oral microbiome. Our results reveal a potent therapeutic synergism using approved agents while providing facile SnF(2) stabilization, to prevent a widespread oral disease with reduced fluoride exposure. Nature Publishing Group UK 2023-09-29 /pmc/articles/PMC10541875/ /pubmed/37773239 http://dx.doi.org/10.1038/s41467-023-41687-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Huang, Yue
Liu, Yuan
Pandey, Nil Kanatha
Shah, Shrey
Simon-Soro, Aurea
Hsu, Jessica C.
Ren, Zhi
Xiang, Zhenting
Kim, Dongyeop
Ito, Tatsuro
Oh, Min Jun
Buckley, Christine
Alawi, Faizan
Li, Yong
Smeets, Paul J. M.
Boyer, Sarah
Zhao, Xingchen
Joester, Derk
Zero, Domenick T.
Cormode, David P.
Koo, Hyun
Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention
title Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention
title_full Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention
title_fullStr Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention
title_full_unstemmed Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention
title_short Iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention
title_sort iron oxide nanozymes stabilize stannous fluoride for targeted biofilm killing and synergistic oral disease prevention
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541875/
https://www.ncbi.nlm.nih.gov/pubmed/37773239
http://dx.doi.org/10.1038/s41467-023-41687-8
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