Multidimensional quantitative phenotypic and molecular analysis reveals neomorphic behaviors of p53 missense mutants

Mutations in the TP53 tumor suppressor gene occur in >80% of the triple-negative or basal-like breast cancer. To test whether neomorphic functions of specific TP53 missense mutations contribute to phenotypic heterogeneity, we characterized phenotypes of non-transformed MCF10A-derived cell lines e...

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Detalles Bibliográficos
Autores principales: Pal, Anasuya, Gonzalez-Malerva, Laura, Eaton, Seron, Xu, Chenxi, Zhang, Yining, Grief, Dustin, Sakala, Lydia, Nwekwo, Lilian, Zeng, Jia, Christensen, Grant, Gupta, Chitrak, Streitwieser, Ellen, Singharoy, Abhishek, Park, Jin G., LaBaer, Joshua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541912/
https://www.ncbi.nlm.nih.gov/pubmed/37773066
http://dx.doi.org/10.1038/s41523-023-00582-7

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