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Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions

Hypoxia is characterized by low oxygen levels in the body or environment, resulting in various physiological and pathological changes. The brain, which has the highest oxygen consumption of any organ, is particularly susceptible to hypoxic injury. Exposure to low-pressure hypoxic environments can ca...

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Autores principales: Yang, Rong, Li, Zheng, Xu, Jing, Luo, Juan, Qu, Zhichuang, Chen, Xin, Yu, Sixun, Shu, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541965/
https://www.ncbi.nlm.nih.gov/pubmed/37786863
http://dx.doi.org/10.3389/fneur.2023.1198546
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author Yang, Rong
Li, Zheng
Xu, Jing
Luo, Juan
Qu, Zhichuang
Chen, Xin
Yu, Sixun
Shu, Haifeng
author_facet Yang, Rong
Li, Zheng
Xu, Jing
Luo, Juan
Qu, Zhichuang
Chen, Xin
Yu, Sixun
Shu, Haifeng
author_sort Yang, Rong
collection PubMed
description Hypoxia is characterized by low oxygen levels in the body or environment, resulting in various physiological and pathological changes. The brain, which has the highest oxygen consumption of any organ, is particularly susceptible to hypoxic injury. Exposure to low-pressure hypoxic environments can cause irreversible brain damage. Hypoxia can occur in healthy individuals at high altitudes or in pathological conditions such as trauma, stroke, inflammation, and autoimmune and neurodegenerative diseases, leading to severe brain damage and impairments in cognitive, learning, and memory functions. Exosomes may play a role in the mechanisms of hypoxic injury and adaptation and are a current focus of research. Investigating changes in exosomes in the central nervous system under hypoxic conditions may aid in preventing secondary damage caused by hypoxia. This paper provides a brief overview of central nervous system injury resulting from hypoxia, and aimed to conduct a comprehensive literature review to assess the pathophysio-logical impact of exosomes on the central nervous system under hypoxic conditions.
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spelling pubmed-105419652023-10-02 Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions Yang, Rong Li, Zheng Xu, Jing Luo, Juan Qu, Zhichuang Chen, Xin Yu, Sixun Shu, Haifeng Front Neurol Neurology Hypoxia is characterized by low oxygen levels in the body or environment, resulting in various physiological and pathological changes. The brain, which has the highest oxygen consumption of any organ, is particularly susceptible to hypoxic injury. Exposure to low-pressure hypoxic environments can cause irreversible brain damage. Hypoxia can occur in healthy individuals at high altitudes or in pathological conditions such as trauma, stroke, inflammation, and autoimmune and neurodegenerative diseases, leading to severe brain damage and impairments in cognitive, learning, and memory functions. Exosomes may play a role in the mechanisms of hypoxic injury and adaptation and are a current focus of research. Investigating changes in exosomes in the central nervous system under hypoxic conditions may aid in preventing secondary damage caused by hypoxia. This paper provides a brief overview of central nervous system injury resulting from hypoxia, and aimed to conduct a comprehensive literature review to assess the pathophysio-logical impact of exosomes on the central nervous system under hypoxic conditions. Frontiers Media S.A. 2023-09-15 /pmc/articles/PMC10541965/ /pubmed/37786863 http://dx.doi.org/10.3389/fneur.2023.1198546 Text en Copyright © 2023 Yang, Li, Xu, Luo, Qu, Chen, Yu and Shu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Yang, Rong
Li, Zheng
Xu, Jing
Luo, Juan
Qu, Zhichuang
Chen, Xin
Yu, Sixun
Shu, Haifeng
Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions
title Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions
title_full Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions
title_fullStr Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions
title_full_unstemmed Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions
title_short Role of hypoxic exosomes and the mechanisms of exosome release in the CNS under hypoxic conditions
title_sort role of hypoxic exosomes and the mechanisms of exosome release in the cns under hypoxic conditions
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10541965/
https://www.ncbi.nlm.nih.gov/pubmed/37786863
http://dx.doi.org/10.3389/fneur.2023.1198546
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