Pro-tumor Tfh2 cells induce detrimental IgG4 production and PGE(2)-dependent IgE inhibition in pancreatic cancer

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis and it is characterized by predominant pro-tumor Th2-type inflammation. T follicular helper (Tfh) cells are relevant immunoregulators in cancer, and often correlate with better survival. How the Th2-skewed microenvironment in...

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Detalles Bibliográficos
Autores principales: De Monte, Lucia, Clemente, Francesca, Ruggiero, Eliana, Pini, Raffaella, Ceraolo, Maria Grazia, Schiavo Lena, Marco, Balestrieri, Chiara, Lazarevic, Dejan, Belfiori, Giulio, Crippa, Stefano, Balzano, Gianpaolo, Falconi, Massimo, Doglioni, Claudio, Bonini, Chiara, Reni, Michele, Protti, Maria Pia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542011/
https://www.ncbi.nlm.nih.gov/pubmed/37776595
http://dx.doi.org/10.1016/j.ebiom.2023.104819

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