Lactate-induced mtDNA Accumulation Activates cGAS-STING Signaling and the Inflammatory Response in Sjögren's Syndrome

Acinar epithelial cell atrophy in secretory glands is a hallmark of primary Sjögren's syndrome (pSS), the cause of which is far from elucidated. We examined the role of acinar atrophy by focusing on the metabolism of glandular epithelial cells and mitochondria in the pSS environment. After conf...

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Detalles Bibliográficos
Autores principales: Xu, Jiabao, Chen, Changyu, Yin, Junhao, Fu, Jiayao, Yang, Xiujuan, Wang, Baoli, Yu, Chuangqi, Zheng, Lingyan, Zhang, Zhiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542019/
https://www.ncbi.nlm.nih.gov/pubmed/37786436
http://dx.doi.org/10.7150/ijms.83801

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