Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer

Pancreatic ductal adenocarcinoma has quickly risen to become the 3(rd) leading cause of cancer-related death. This is in part due to its fibrotic tumor microenvironment (TME) that contributes to poor vascularization and immune infiltration and subsequent chemo- and immunotherapy failure. Here we inv...

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Detalles Bibliográficos
Autores principales: Chibaya, Loretah, Lusi, Christina F., DeMarco, Kelly D., Kane, Griffin I., Brassil, Meghan L., Parikh, Chaitanya N., Murphy, Katherine C., Li, Junhui, Naylor, Tiana E., Cerrutti, Julia, Peura, Jessica, Pitarresi, Jason R., Zhu, Lihua Julie, Fitzgerald, Katherine A., Atukorale, Prabhani U., Ruscetti, Marcus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542133/
https://www.ncbi.nlm.nih.gov/pubmed/37790484
http://dx.doi.org/10.1101/2023.09.18.558307

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