Double-Strand Break Repair Pathways Differentially Affect Processing and Transduction by Dual AAV Vectors

Recombinant adeno-associated viral vectors (rAAV) are a powerful tool for gene delivery but have a limited DNA carrying capacity. Efforts to expand this genetic payload have focused on engineering the vector components, such as dual trans-splicing vectors which double the delivery size by exploiting...

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Detalles Bibliográficos
Autores principales: Maurer, Anna C., Benyamini, Brian, Fan, Vinson B., Whitney, Oscar N., Dailey, Gina M., Darzacq, Xavier, Weitzman, Matthew D., Tjian, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542147/
https://www.ncbi.nlm.nih.gov/pubmed/37790316
http://dx.doi.org/10.1101/2023.09.19.558438

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542147/
https://www.ncbi.nlm.nih.gov/pubmed/37790316
http://dx.doi.org/10.1101/2023.09.19.558438

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