Glutamylation of Npm2 and Nap1 acidic disordered regions increases DNA charge mimicry to enhance chaperone efficiency

Histone chaperones–structurally diverse, non-catalytic proteins enriched with acidic intrinsically disordered regions (IDRs)–protect histones from spurious nucleic acid interactions and guide their deposition into and out of nucleosomes. Despite their conservation and ubiquity, the function of the c...

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Detalles Bibliográficos
Autores principales: Lorton, Benjamin M., Warren, Christopher, Ilyas, Humaira, Nandigrami, Prithviraj, Hegde, Subray, Cahill, Sean, Lehman, Stephanie M, Shabanowitz, Jeffrey, Hunt, Donald F., Fiser, Andras, Cowburn, David, Shechter, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542154/
https://www.ncbi.nlm.nih.gov/pubmed/37790377
http://dx.doi.org/10.1101/2023.09.18.558337

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