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Cryo-EM structure of Alzheimer’s disease tau filaments with PET ligand MK-6240

Positron Emission Tomography (PET) ligands have advanced Alzheimer’s disease (AD) diagnosis and treatment. Using autoradiography and cryo-EM, we identified AD brain tissue with elevated tau burden, purified filaments, and determined the structure of second-generation high avidity PET ligand MK-6240...

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Detalles Bibliográficos
Autores principales:	Kunach, Peter, Vaquer-Alicea, Jaime, Smith, Matthew S., Hopewell, Robert, Monistrol, Jim, Moquin, Luc, Therriault, Joseph, Tissot, Cecile, Rahmouni, Nesrine, Massarweh, Gassan, Soucy, Jean-Paul, Guiot, Marie-Christine, Shoichet, Brian K., Rosa-Neto, Pedro, Diamond, Marc I., Shahmoradian, Sarah H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542181/ https://www.ncbi.nlm.nih.gov/pubmed/37790438 http://dx.doi.org/10.1101/2023.09.22.558671

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