Efficient targeted recombination with CRISPR/Cas9 in hybrids of Caenorhabditis nematodes with suppressed recombination

BACKGROUND: Homology-based recombination (HR) is the cornerstone of genetic mapping. However, a lack of sufficient sequence homology or the presence of a genomic rearrangement prevents HR through crossing, which inhibits genetic mapping in relevant genomic regions. This is particularly true in speci...

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Detalles Bibliográficos
Autores principales: Xie, Dongying, Gu, Bida, Liu, Yiqing, Ye, Pohao, Ma, Yiming, Wen, Tongshu, Song, Xiaoyuan, Zhao, Zhongying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Methodology Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542263/
https://www.ncbi.nlm.nih.gov/pubmed/37775783
http://dx.doi.org/10.1186/s12915-023-01704-0

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