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Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus)

There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative pr...

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Autores principales: Nguyen, Elizabeth Dong, Fard, Vahid Nikoonejad, Kim, Bernard Y, Collins, Sarah, Galey, Miranda, Nelson, Branden R, Wakenight, Paul, Gable, Simone M, McKenna, Aaron, Bammler, Theo K, MacDonald, Jim, Okamura, Daryl M, Shendure, Jay, Beier, David R, Ramirez, Jan Marino, Majesky, Mark W, Millen, Kathleen J, Tollis, Marc, Miller, Danny E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542272/
https://www.ncbi.nlm.nih.gov/pubmed/37552705
http://dx.doi.org/10.1093/g3journal/jkad177
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author Nguyen, Elizabeth Dong
Fard, Vahid Nikoonejad
Kim, Bernard Y
Collins, Sarah
Galey, Miranda
Nelson, Branden R
Wakenight, Paul
Gable, Simone M
McKenna, Aaron
Bammler, Theo K
MacDonald, Jim
Okamura, Daryl M
Shendure, Jay
Beier, David R
Ramirez, Jan Marino
Majesky, Mark W
Millen, Kathleen J
Tollis, Marc
Miller, Danny E
author_facet Nguyen, Elizabeth Dong
Fard, Vahid Nikoonejad
Kim, Bernard Y
Collins, Sarah
Galey, Miranda
Nelson, Branden R
Wakenight, Paul
Gable, Simone M
McKenna, Aaron
Bammler, Theo K
MacDonald, Jim
Okamura, Daryl M
Shendure, Jay
Beier, David R
Ramirez, Jan Marino
Majesky, Mark W
Millen, Kathleen J
Tollis, Marc
Miller, Danny E
author_sort Nguyen, Elizabeth Dong
collection PubMed
description There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative properties at the molecular level. Here, we present an improved reference genome for A. cahirinus generated from long Nanopore sequencing reads. We confirm the quality of our annotations using RNA sequencing data from 4 different tissues. Our genome is of higher contiguity and quality than previously reported genomes from this species and will facilitate ongoing efforts to better understand the regenerative properties of this organism.
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spelling pubmed-105422722023-10-03 Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus) Nguyen, Elizabeth Dong Fard, Vahid Nikoonejad Kim, Bernard Y Collins, Sarah Galey, Miranda Nelson, Branden R Wakenight, Paul Gable, Simone M McKenna, Aaron Bammler, Theo K MacDonald, Jim Okamura, Daryl M Shendure, Jay Beier, David R Ramirez, Jan Marino Majesky, Mark W Millen, Kathleen J Tollis, Marc Miller, Danny E G3 (Bethesda) Genome Report There is increasing interest in the African spiny mouse (Acomys cahirinus) as a model organism because of its ability for regeneration of tissue after injury in skin, muscle, and internal organs such as the kidneys. A high-quality reference genome is needed to better understand these regenerative properties at the molecular level. Here, we present an improved reference genome for A. cahirinus generated from long Nanopore sequencing reads. We confirm the quality of our annotations using RNA sequencing data from 4 different tissues. Our genome is of higher contiguity and quality than previously reported genomes from this species and will facilitate ongoing efforts to better understand the regenerative properties of this organism. Oxford University Press 2023-08-08 /pmc/articles/PMC10542272/ /pubmed/37552705 http://dx.doi.org/10.1093/g3journal/jkad177 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of The Genetics Society of America. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Genome Report
Nguyen, Elizabeth Dong
Fard, Vahid Nikoonejad
Kim, Bernard Y
Collins, Sarah
Galey, Miranda
Nelson, Branden R
Wakenight, Paul
Gable, Simone M
McKenna, Aaron
Bammler, Theo K
MacDonald, Jim
Okamura, Daryl M
Shendure, Jay
Beier, David R
Ramirez, Jan Marino
Majesky, Mark W
Millen, Kathleen J
Tollis, Marc
Miller, Danny E
Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus)
title Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus)
title_full Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus)
title_fullStr Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus)
title_full_unstemmed Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus)
title_short Genome Report: chromosome-scale genome assembly of the African spiny mouse (Acomys cahirinus)
title_sort genome report: chromosome-scale genome assembly of the african spiny mouse (acomys cahirinus)
topic Genome Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542272/
https://www.ncbi.nlm.nih.gov/pubmed/37552705
http://dx.doi.org/10.1093/g3journal/jkad177
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