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A CK2 and SUMO-dependent, PML NB-involved regulatory mechanism controlling BLM ubiquitination and G-quadruplex resolution

The Boom syndrome helicase (BLM) unwinds a variety of DNA structures such as Guanine (G)-quadruplex. Here we reveal a role of RNF111/Arkadia and its paralog ARKL1, as well as Promyelocytic Leukemia Nuclear Bodies (PML NBs), in the regulation of ubiquitination and control of BLM protein levels. RNF11...

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Detalles Bibliográficos
Autores principales: Liu, Shichang, Atkinson, Erin, Paulucci-Holthauzen, Adriana, Wang, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542384/
https://www.ncbi.nlm.nih.gov/pubmed/37777511
http://dx.doi.org/10.1038/s41467-023-41705-9

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