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Legumes and nuts intake in relation to metabolic health status, serum brain derived neurotrophic factor and adropin levels in adults

There is controversial evidence about the relationship between consumption of legumes and nuts with metabolic disturbances. The present study was undertaken to explore the association of legumes and nuts intake with metabolic health status among Iranian adults. This cross-sectional study was conduct...

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Autores principales: Assi, Mohammad Javad, Poursalehi, Donya, Tirani, Shahnaz Amani, Shahdadian, Farnaz, Hajhashemy, Zahra, Mokhtari, Elahe, Mohammadi, Sobhan, Saneei, Parvane
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542386/
https://www.ncbi.nlm.nih.gov/pubmed/37777675
http://dx.doi.org/10.1038/s41598-023-43855-8
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author Assi, Mohammad Javad
Poursalehi, Donya
Tirani, Shahnaz Amani
Shahdadian, Farnaz
Hajhashemy, Zahra
Mokhtari, Elahe
Mohammadi, Sobhan
Saneei, Parvane
author_facet Assi, Mohammad Javad
Poursalehi, Donya
Tirani, Shahnaz Amani
Shahdadian, Farnaz
Hajhashemy, Zahra
Mokhtari, Elahe
Mohammadi, Sobhan
Saneei, Parvane
author_sort Assi, Mohammad Javad
collection PubMed
description There is controversial evidence about the relationship between consumption of legumes and nuts with metabolic disturbances. The present study was undertaken to explore the association of legumes and nuts intake with metabolic health status among Iranian adults. This cross-sectional study was conducted on 527 adults (45.7% female, aged 20–65 years) chosen through a multistage cluster random-sampling approach. Dietary intakes of individuals were assessed using a validated food frequency questionnaire. Fasting blood samples were gathered to evaluate biochemical parameters. Metabolic health status of subjects was determined according to the criteria defined by Wildman. Data of covariates were collected using pre-tested procedures. The overall prevalence of metabolic unhealthy (MU) phenotype was 42.5%. After controlling all confounders, participants with highest intake of legumes and nuts had lower odds of MU status, compared with the lowest intake (OR 0.35; 95% CI 0.18–0.71). This association was stronger in normal-weight rather than overweight/obese adults and also in women rather than men. Higher consumption of legumes and nuts was additionally related to decreased odds of hyperglycemia, hypertriglyceridemia, and hypertension. A marginally inverse association was observed between legumes and nuts intake with low brain-derived neurotrophic factor (BDNF) levels, in fully-adjusted model (OR(T3 vs. T1) 0.50; 95% CI 0.25–1.01). Each tertile increase in legumes and nuts intake was marginally related to higher adropin levels ([Formula: see text] = 4.06; P = 0.07). In conclusion, this study demonstrated that higher intake of legumes and nuts is associated with lower chance of MU both in normal weight and overweight/obese adults. The association may be facilitated through serum BDNF and adropin.
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spelling pubmed-105423862023-10-03 Legumes and nuts intake in relation to metabolic health status, serum brain derived neurotrophic factor and adropin levels in adults Assi, Mohammad Javad Poursalehi, Donya Tirani, Shahnaz Amani Shahdadian, Farnaz Hajhashemy, Zahra Mokhtari, Elahe Mohammadi, Sobhan Saneei, Parvane Sci Rep Article There is controversial evidence about the relationship between consumption of legumes and nuts with metabolic disturbances. The present study was undertaken to explore the association of legumes and nuts intake with metabolic health status among Iranian adults. This cross-sectional study was conducted on 527 adults (45.7% female, aged 20–65 years) chosen through a multistage cluster random-sampling approach. Dietary intakes of individuals were assessed using a validated food frequency questionnaire. Fasting blood samples were gathered to evaluate biochemical parameters. Metabolic health status of subjects was determined according to the criteria defined by Wildman. Data of covariates were collected using pre-tested procedures. The overall prevalence of metabolic unhealthy (MU) phenotype was 42.5%. After controlling all confounders, participants with highest intake of legumes and nuts had lower odds of MU status, compared with the lowest intake (OR 0.35; 95% CI 0.18–0.71). This association was stronger in normal-weight rather than overweight/obese adults and also in women rather than men. Higher consumption of legumes and nuts was additionally related to decreased odds of hyperglycemia, hypertriglyceridemia, and hypertension. A marginally inverse association was observed between legumes and nuts intake with low brain-derived neurotrophic factor (BDNF) levels, in fully-adjusted model (OR(T3 vs. T1) 0.50; 95% CI 0.25–1.01). Each tertile increase in legumes and nuts intake was marginally related to higher adropin levels ([Formula: see text] = 4.06; P = 0.07). In conclusion, this study demonstrated that higher intake of legumes and nuts is associated with lower chance of MU both in normal weight and overweight/obese adults. The association may be facilitated through serum BDNF and adropin. Nature Publishing Group UK 2023-09-30 /pmc/articles/PMC10542386/ /pubmed/37777675 http://dx.doi.org/10.1038/s41598-023-43855-8 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Assi, Mohammad Javad
Poursalehi, Donya
Tirani, Shahnaz Amani
Shahdadian, Farnaz
Hajhashemy, Zahra
Mokhtari, Elahe
Mohammadi, Sobhan
Saneei, Parvane
Legumes and nuts intake in relation to metabolic health status, serum brain derived neurotrophic factor and adropin levels in adults
title Legumes and nuts intake in relation to metabolic health status, serum brain derived neurotrophic factor and adropin levels in adults
title_full Legumes and nuts intake in relation to metabolic health status, serum brain derived neurotrophic factor and adropin levels in adults
title_fullStr Legumes and nuts intake in relation to metabolic health status, serum brain derived neurotrophic factor and adropin levels in adults
title_full_unstemmed Legumes and nuts intake in relation to metabolic health status, serum brain derived neurotrophic factor and adropin levels in adults
title_short Legumes and nuts intake in relation to metabolic health status, serum brain derived neurotrophic factor and adropin levels in adults
title_sort legumes and nuts intake in relation to metabolic health status, serum brain derived neurotrophic factor and adropin levels in adults
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542386/
https://www.ncbi.nlm.nih.gov/pubmed/37777675
http://dx.doi.org/10.1038/s41598-023-43855-8
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