The role of angiogenic growth factors in the immune microenvironment of glioma

Angiogenic growth factors (AGFs) are a class of secreted cytokines related to angiogenesis that mainly include vascular endothelial growth factors (VEGFs), stromal-derived factor-1 (SDF-1), platelet-derived growth factors (PDGFs), fibroblast growth factors (FGFs), transforming growth factor-beta (TG...

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Detalles Bibliográficos
Autores principales: Ge, Zhengmao, Zhang, Qi, Lin, Wei, Jiang, Xiaofan, Zhang, Yanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542410/
https://www.ncbi.nlm.nih.gov/pubmed/37790751
http://dx.doi.org/10.3389/fonc.2023.1254694
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author Ge, Zhengmao
Zhang, Qi
Lin, Wei
Jiang, Xiaofan
Zhang, Yanyu
author_facet Ge, Zhengmao
Zhang, Qi
Lin, Wei
Jiang, Xiaofan
Zhang, Yanyu
author_sort Ge, Zhengmao
collection PubMed
description Angiogenic growth factors (AGFs) are a class of secreted cytokines related to angiogenesis that mainly include vascular endothelial growth factors (VEGFs), stromal-derived factor-1 (SDF-1), platelet-derived growth factors (PDGFs), fibroblast growth factors (FGFs), transforming growth factor-beta (TGF-β) and angiopoietins (ANGs). Accumulating evidence indicates that the role of AGFs is not only limited to tumor angiogenesis but also participating in tumor progression by other mechanisms that go beyond their angiogenic role. AGFs were shown to be upregulated in the glioma microenvironment characterized by extensive angiogenesis and high immunosuppression. AGFs produced by tumor and stromal cells can exert an immunomodulatory role in the glioma microenvironment by interacting with immune cells. This review aims to sum up the interactions among AGFs, immune cells and cancer cells with a particular emphasis on glioma and tries to provide new perspectives for understanding the glioma immune microenvironment and in-depth explorations for anti-glioma therapy.
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spelling pubmed-105424102023-10-03 The role of angiogenic growth factors in the immune microenvironment of glioma Ge, Zhengmao Zhang, Qi Lin, Wei Jiang, Xiaofan Zhang, Yanyu Front Oncol Oncology Angiogenic growth factors (AGFs) are a class of secreted cytokines related to angiogenesis that mainly include vascular endothelial growth factors (VEGFs), stromal-derived factor-1 (SDF-1), platelet-derived growth factors (PDGFs), fibroblast growth factors (FGFs), transforming growth factor-beta (TGF-β) and angiopoietins (ANGs). Accumulating evidence indicates that the role of AGFs is not only limited to tumor angiogenesis but also participating in tumor progression by other mechanisms that go beyond their angiogenic role. AGFs were shown to be upregulated in the glioma microenvironment characterized by extensive angiogenesis and high immunosuppression. AGFs produced by tumor and stromal cells can exert an immunomodulatory role in the glioma microenvironment by interacting with immune cells. This review aims to sum up the interactions among AGFs, immune cells and cancer cells with a particular emphasis on glioma and tries to provide new perspectives for understanding the glioma immune microenvironment and in-depth explorations for anti-glioma therapy. Frontiers Media S.A. 2023-09-13 /pmc/articles/PMC10542410/ /pubmed/37790751 http://dx.doi.org/10.3389/fonc.2023.1254694 Text en Copyright © 2023 Ge, Zhang, Lin, Jiang and Zhang https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Ge, Zhengmao
Zhang, Qi
Lin, Wei
Jiang, Xiaofan
Zhang, Yanyu
The role of angiogenic growth factors in the immune microenvironment of glioma
title The role of angiogenic growth factors in the immune microenvironment of glioma
title_full The role of angiogenic growth factors in the immune microenvironment of glioma
title_fullStr The role of angiogenic growth factors in the immune microenvironment of glioma
title_full_unstemmed The role of angiogenic growth factors in the immune microenvironment of glioma
title_short The role of angiogenic growth factors in the immune microenvironment of glioma
title_sort role of angiogenic growth factors in the immune microenvironment of glioma
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542410/
https://www.ncbi.nlm.nih.gov/pubmed/37790751
http://dx.doi.org/10.3389/fonc.2023.1254694
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