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Male violence disrupts estrogen receptor β signaling in the female hippocampus
Women are the main target of intimate partner violence (IPV), which is escalating worldwide. Mechanisms subtending IPV-related disorders, such as anxiety, depression and PTSD, remain unclear. We employed a mouse model molded on an IPV scenario (male vs. female prolonged violent interaction) to unear...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cold Spring Harbor Laboratory
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542497/ https://www.ncbi.nlm.nih.gov/pubmed/37790349 http://dx.doi.org/10.1101/2023.09.23.559092 |
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author | Agrimi, Jacopo Bernardele, Lucia Sbaiti, Naeem Canato, Marta Marchionni, Ivan Oeing, Christian U. Vignoli, Beatrice Canossa, Marco Kaludercic, Nina Lodovichi, Claudia Dal Maschio, Marco Paolocci, Nazareno |
author_facet | Agrimi, Jacopo Bernardele, Lucia Sbaiti, Naeem Canato, Marta Marchionni, Ivan Oeing, Christian U. Vignoli, Beatrice Canossa, Marco Kaludercic, Nina Lodovichi, Claudia Dal Maschio, Marco Paolocci, Nazareno |
author_sort | Agrimi, Jacopo |
collection | PubMed |
description | Women are the main target of intimate partner violence (IPV), which is escalating worldwide. Mechanisms subtending IPV-related disorders, such as anxiety, depression and PTSD, remain unclear. We employed a mouse model molded on an IPV scenario (male vs. female prolonged violent interaction) to unearth the neuroendocrine alterations triggered by an aggressive male mouse on the female murine brain. Experimental IPV (EIPV) prompted marked anxiety-like behavior in young female mice, coincident with high circulating/cerebral corticosterone levels. The hippocampus of EIPV-inflicted female animals displayed neuronal loss, reduced BrdU-DCX-positive nuclei, decreased mature DCX-positive cells, and diminished dendritic arborization level in the dentate gyrus (DG), features denoting impaired neurogenesis and neuronal differentiation. These hallmarks were associated with marked down-regulation of estrogen receptor β (ERβ) density in the hippocampus, especially in the DG and dependent prosurvival ERK signaling. Conversely, ERα expression was unchanged. After EIPV, the DG harbored lowered local BDNF pools, diminished TrkB phosphorylation, and elevated glucocorticoid receptor phosphorylation. In unison, ERβ KO mice had heightened anxiety-like behavior and curtailed BDNF levels at baseline, despite enhanced circulating estradiol levels, while dying prematurely during EIPV. Thus, reiterated male-to-female violence jeopardizes hippocampal homeostasis in the female brain, perturbing ERβ/BDNF signaling, thus instigating anxiety and chronic stress. |
format | Online Article Text |
id | pubmed-10542497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Cold Spring Harbor Laboratory |
record_format | MEDLINE/PubMed |
spelling | pubmed-105424972023-10-03 Male violence disrupts estrogen receptor β signaling in the female hippocampus Agrimi, Jacopo Bernardele, Lucia Sbaiti, Naeem Canato, Marta Marchionni, Ivan Oeing, Christian U. Vignoli, Beatrice Canossa, Marco Kaludercic, Nina Lodovichi, Claudia Dal Maschio, Marco Paolocci, Nazareno bioRxiv Article Women are the main target of intimate partner violence (IPV), which is escalating worldwide. Mechanisms subtending IPV-related disorders, such as anxiety, depression and PTSD, remain unclear. We employed a mouse model molded on an IPV scenario (male vs. female prolonged violent interaction) to unearth the neuroendocrine alterations triggered by an aggressive male mouse on the female murine brain. Experimental IPV (EIPV) prompted marked anxiety-like behavior in young female mice, coincident with high circulating/cerebral corticosterone levels. The hippocampus of EIPV-inflicted female animals displayed neuronal loss, reduced BrdU-DCX-positive nuclei, decreased mature DCX-positive cells, and diminished dendritic arborization level in the dentate gyrus (DG), features denoting impaired neurogenesis and neuronal differentiation. These hallmarks were associated with marked down-regulation of estrogen receptor β (ERβ) density in the hippocampus, especially in the DG and dependent prosurvival ERK signaling. Conversely, ERα expression was unchanged. After EIPV, the DG harbored lowered local BDNF pools, diminished TrkB phosphorylation, and elevated glucocorticoid receptor phosphorylation. In unison, ERβ KO mice had heightened anxiety-like behavior and curtailed BDNF levels at baseline, despite enhanced circulating estradiol levels, while dying prematurely during EIPV. Thus, reiterated male-to-female violence jeopardizes hippocampal homeostasis in the female brain, perturbing ERβ/BDNF signaling, thus instigating anxiety and chronic stress. Cold Spring Harbor Laboratory 2023-09-23 /pmc/articles/PMC10542497/ /pubmed/37790349 http://dx.doi.org/10.1101/2023.09.23.559092 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
spellingShingle | Article Agrimi, Jacopo Bernardele, Lucia Sbaiti, Naeem Canato, Marta Marchionni, Ivan Oeing, Christian U. Vignoli, Beatrice Canossa, Marco Kaludercic, Nina Lodovichi, Claudia Dal Maschio, Marco Paolocci, Nazareno Male violence disrupts estrogen receptor β signaling in the female hippocampus |
title | Male violence disrupts estrogen receptor β signaling in the female hippocampus |
title_full | Male violence disrupts estrogen receptor β signaling in the female hippocampus |
title_fullStr | Male violence disrupts estrogen receptor β signaling in the female hippocampus |
title_full_unstemmed | Male violence disrupts estrogen receptor β signaling in the female hippocampus |
title_short | Male violence disrupts estrogen receptor β signaling in the female hippocampus |
title_sort | male violence disrupts estrogen receptor β signaling in the female hippocampus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542497/ https://www.ncbi.nlm.nih.gov/pubmed/37790349 http://dx.doi.org/10.1101/2023.09.23.559092 |
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