Activity-induced gene expression in the human brain

Activity-induced gene expression underlies synaptic plasticity and brain function. Here, using molecular sequencing techniques, we define activity-dependent transcriptomic and epigenomic changes at the tissue and single-cell level in the human brain following direct electrical stimulation of the ant...

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Detalles Bibliográficos
Autores principales: Chatterjee, Snehajyoti, Park, Brian J., Vanrobaeys, Yann, Heiney, Shane A., Rhone, Ariane E., Nourski, Kirill V., Langmack, Lucy, Mukherjee, Utsav, Kovach, Christopher K., Kocsis, Zsuzsanna, Kikuchi, Yukiko, Petkov, Christopher I., Hefti, Marco M., Bahl, Ethan, Michaelson, Jacob J, Kawasaki, Hiroto, Oya, Hiroyuki, Howard, Matthew A., Nickl-Jockschat, Thomas, Lin, Li-Chun, Abel, Ted
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542502/
https://www.ncbi.nlm.nih.gov/pubmed/37790527
http://dx.doi.org/10.1101/2023.09.21.558812
Descripción
Sumario:Activity-induced gene expression underlies synaptic plasticity and brain function. Here, using molecular sequencing techniques, we define activity-dependent transcriptomic and epigenomic changes at the tissue and single-cell level in the human brain following direct electrical stimulation of the anterior temporal lobe in patients undergoing neurosurgery. Genes related to transcriptional regulation and microglia-specific cytokine activity displayed the greatest induction pattern, revealing a precise molecular signature of neuronal activation in the human brain.

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