Cargando…
Activity-induced gene expression in the human brain
Activity-induced gene expression underlies synaptic plasticity and brain function. Here, using molecular sequencing techniques, we define activity-dependent transcriptomic and epigenomic changes at the tissue and single-cell level in the human brain following direct electrical stimulation of the ant...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Cold Spring Harbor Laboratory
2023
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542502/ https://www.ncbi.nlm.nih.gov/pubmed/37790527 http://dx.doi.org/10.1101/2023.09.21.558812 |
| _version_ | 1785114107046789120 |
|---|---|
| author | Chatterjee, Snehajyoti Park, Brian J. Vanrobaeys, Yann Heiney, Shane A. Rhone, Ariane E. Nourski, Kirill V. Langmack, Lucy Mukherjee, Utsav Kovach, Christopher K. Kocsis, Zsuzsanna Kikuchi, Yukiko Petkov, Christopher I. Hefti, Marco M. Bahl, Ethan Michaelson, Jacob J Kawasaki, Hiroto Oya, Hiroyuki Howard, Matthew A. Nickl-Jockschat, Thomas Lin, Li-Chun Abel, Ted |
| author_facet | Chatterjee, Snehajyoti Park, Brian J. Vanrobaeys, Yann Heiney, Shane A. Rhone, Ariane E. Nourski, Kirill V. Langmack, Lucy Mukherjee, Utsav Kovach, Christopher K. Kocsis, Zsuzsanna Kikuchi, Yukiko Petkov, Christopher I. Hefti, Marco M. Bahl, Ethan Michaelson, Jacob J Kawasaki, Hiroto Oya, Hiroyuki Howard, Matthew A. Nickl-Jockschat, Thomas Lin, Li-Chun Abel, Ted |
| author_sort | Chatterjee, Snehajyoti |
| collection | PubMed |
| description | Activity-induced gene expression underlies synaptic plasticity and brain function. Here, using molecular sequencing techniques, we define activity-dependent transcriptomic and epigenomic changes at the tissue and single-cell level in the human brain following direct electrical stimulation of the anterior temporal lobe in patients undergoing neurosurgery. Genes related to transcriptional regulation and microglia-specific cytokine activity displayed the greatest induction pattern, revealing a precise molecular signature of neuronal activation in the human brain. |
| format | Online Article Text |
| id | pubmed-10542502 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Cold Spring Harbor Laboratory |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-105425022023-10-03 Activity-induced gene expression in the human brain Chatterjee, Snehajyoti Park, Brian J. Vanrobaeys, Yann Heiney, Shane A. Rhone, Ariane E. Nourski, Kirill V. Langmack, Lucy Mukherjee, Utsav Kovach, Christopher K. Kocsis, Zsuzsanna Kikuchi, Yukiko Petkov, Christopher I. Hefti, Marco M. Bahl, Ethan Michaelson, Jacob J Kawasaki, Hiroto Oya, Hiroyuki Howard, Matthew A. Nickl-Jockschat, Thomas Lin, Li-Chun Abel, Ted bioRxiv Article Activity-induced gene expression underlies synaptic plasticity and brain function. Here, using molecular sequencing techniques, we define activity-dependent transcriptomic and epigenomic changes at the tissue and single-cell level in the human brain following direct electrical stimulation of the anterior temporal lobe in patients undergoing neurosurgery. Genes related to transcriptional regulation and microglia-specific cytokine activity displayed the greatest induction pattern, revealing a precise molecular signature of neuronal activation in the human brain. Cold Spring Harbor Laboratory 2023-09-21 /pmc/articles/PMC10542502/ /pubmed/37790527 http://dx.doi.org/10.1101/2023.09.21.558812 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator. |
| spellingShingle | Article Chatterjee, Snehajyoti Park, Brian J. Vanrobaeys, Yann Heiney, Shane A. Rhone, Ariane E. Nourski, Kirill V. Langmack, Lucy Mukherjee, Utsav Kovach, Christopher K. Kocsis, Zsuzsanna Kikuchi, Yukiko Petkov, Christopher I. Hefti, Marco M. Bahl, Ethan Michaelson, Jacob J Kawasaki, Hiroto Oya, Hiroyuki Howard, Matthew A. Nickl-Jockschat, Thomas Lin, Li-Chun Abel, Ted Activity-induced gene expression in the human brain |
| title | Activity-induced gene expression in the human brain |
| title_full | Activity-induced gene expression in the human brain |
| title_fullStr | Activity-induced gene expression in the human brain |
| title_full_unstemmed | Activity-induced gene expression in the human brain |
| title_short | Activity-induced gene expression in the human brain |
| title_sort | activity-induced gene expression in the human brain |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542502/ https://www.ncbi.nlm.nih.gov/pubmed/37790527 http://dx.doi.org/10.1101/2023.09.21.558812 |
| work_keys_str_mv | AT chatterjeesnehajyoti activityinducedgeneexpressioninthehumanbrain AT parkbrianj activityinducedgeneexpressioninthehumanbrain AT vanrobaeysyann activityinducedgeneexpressioninthehumanbrain AT heineyshanea activityinducedgeneexpressioninthehumanbrain AT rhonearianee activityinducedgeneexpressioninthehumanbrain AT nourskikirillv activityinducedgeneexpressioninthehumanbrain AT langmacklucy activityinducedgeneexpressioninthehumanbrain AT mukherjeeutsav activityinducedgeneexpressioninthehumanbrain AT kovachchristopherk activityinducedgeneexpressioninthehumanbrain AT kocsiszsuzsanna activityinducedgeneexpressioninthehumanbrain AT kikuchiyukiko activityinducedgeneexpressioninthehumanbrain AT petkovchristopheri activityinducedgeneexpressioninthehumanbrain AT heftimarcom activityinducedgeneexpressioninthehumanbrain AT bahlethan activityinducedgeneexpressioninthehumanbrain AT michaelsonjacobj activityinducedgeneexpressioninthehumanbrain AT kawasakihiroto activityinducedgeneexpressioninthehumanbrain AT oyahiroyuki activityinducedgeneexpressioninthehumanbrain AT howardmatthewa activityinducedgeneexpressioninthehumanbrain AT nickljockschatthomas activityinducedgeneexpressioninthehumanbrain AT linlichun activityinducedgeneexpressioninthehumanbrain AT abelted activityinducedgeneexpressioninthehumanbrain |