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Asymmetric Contribution of a Selectivity Filter Gate in Triggering Inactivation of Ca(V)1.3 Channels

Voltage-dependent and Ca(2+)-dependent inactivation (VDI and CDI, respectively) of Ca(V) channels are two biologically consequential feedback mechanisms that fine-tune Ca(2+) entry into neurons and cardiomyocytes. Although known to be initiated by distinct molecular events, how these processes obstr...

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Detalles Bibliográficos
Autores principales: del Rivero Morfin, Pedro J., Kochiss, Audrey L., Liedl, Klaus R., Flucher, Bernhard E., Fernández-Quintero, Monica L.I., Ben-Johny, Manu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542529/
https://www.ncbi.nlm.nih.gov/pubmed/37790368
http://dx.doi.org/10.1101/2023.09.21.558864