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TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses

B cells can express pro-inflammatory cytokines that promote a wide variety of immune responses. Here we show that B cells expressing the phosphatidylserine receptor TIM-4, preferentially express not only IL-17A, but also IL-22, IL-6, and GM-CSF - a collection of cytokines reminiscent of pathogenic T...

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Autores principales: Ding, Qing, Wu, Yufan, Triglia, Elena Torlai, Gommerman, Jennifer L., Subramanian, Ayshwarya, Kuchroo, Vijay K., Rothstein, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542535/
https://www.ncbi.nlm.nih.gov/pubmed/37790513
http://dx.doi.org/10.1101/2023.09.22.558524
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author Ding, Qing
Wu, Yufan
Triglia, Elena Torlai
Gommerman, Jennifer L.
Subramanian, Ayshwarya
Kuchroo, Vijay K.
Rothstein, David M.
author_facet Ding, Qing
Wu, Yufan
Triglia, Elena Torlai
Gommerman, Jennifer L.
Subramanian, Ayshwarya
Kuchroo, Vijay K.
Rothstein, David M.
author_sort Ding, Qing
collection PubMed
description B cells can express pro-inflammatory cytokines that promote a wide variety of immune responses. Here we show that B cells expressing the phosphatidylserine receptor TIM-4, preferentially express not only IL-17A, but also IL-22, IL-6, and GM-CSF - a collection of cytokines reminiscent of pathogenic Th17 cells. Expression of this proinflammatory module requires B cell expression of IL-23R, RORγt and IL-17. IL-17 expressed by TIM-4(+) B cells not only enhances the severity of experimental autoimmune encephalomyelitis (EAE) and promotes allograft rejection, but also acts in an autocrine manner to prevent their conversion into IL-10-expressing B cells with regulatory function. Thus, IL-17 acts as an inflammatory mediator and also enforces the proinflammatory activity of TIM-4(+) B cells. TIM-4 serves as a broad marker for effector B cells (Beff) that will allow the study of the signals regulating their differentiation and expression of their effector molecules.
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spelling pubmed-105425352023-10-03 TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses Ding, Qing Wu, Yufan Triglia, Elena Torlai Gommerman, Jennifer L. Subramanian, Ayshwarya Kuchroo, Vijay K. Rothstein, David M. bioRxiv Article B cells can express pro-inflammatory cytokines that promote a wide variety of immune responses. Here we show that B cells expressing the phosphatidylserine receptor TIM-4, preferentially express not only IL-17A, but also IL-22, IL-6, and GM-CSF - a collection of cytokines reminiscent of pathogenic Th17 cells. Expression of this proinflammatory module requires B cell expression of IL-23R, RORγt and IL-17. IL-17 expressed by TIM-4(+) B cells not only enhances the severity of experimental autoimmune encephalomyelitis (EAE) and promotes allograft rejection, but also acts in an autocrine manner to prevent their conversion into IL-10-expressing B cells with regulatory function. Thus, IL-17 acts as an inflammatory mediator and also enforces the proinflammatory activity of TIM-4(+) B cells. TIM-4 serves as a broad marker for effector B cells (Beff) that will allow the study of the signals regulating their differentiation and expression of their effector molecules. Cold Spring Harbor Laboratory 2023-09-23 /pmc/articles/PMC10542535/ /pubmed/37790513 http://dx.doi.org/10.1101/2023.09.22.558524 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Ding, Qing
Wu, Yufan
Triglia, Elena Torlai
Gommerman, Jennifer L.
Subramanian, Ayshwarya
Kuchroo, Vijay K.
Rothstein, David M.
TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses
title TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses
title_full TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses
title_fullStr TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses
title_full_unstemmed TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses
title_short TIM-4 Identifies Effector B Cells Expressing An IL-23-Driven Proinflammatory Cytokine Module That Promotes Immune Responses
title_sort tim-4 identifies effector b cells expressing an il-23-driven proinflammatory cytokine module that promotes immune responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542535/
https://www.ncbi.nlm.nih.gov/pubmed/37790513
http://dx.doi.org/10.1101/2023.09.22.558524
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