Cargando…

Target-based discovery of a broad spectrum flukicide

Diseases caused by parasitic flatworms impart a considerable healthcare burden worldwide. Many of these diseases – for example, the parasitic blood fluke infection, schistosomiasis – are treated with the drug praziquantel (PZQ). However, PZQ is ineffective against disease caused by liver flukes from...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sprague, Daniel J., Park, Sang-Kyu, Gramberg, Svenja, Bauer, Lisa, Rohr, Claudia M., Chulkov, Evgeny G., Smith, Emery, Scampavia, Louis, Spicer, Timothy P., Haeberlein, Simone, Marchant, Jonathan S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542552/ https://www.ncbi.nlm.nih.gov/pubmed/37790347 http://dx.doi.org/10.1101/2023.09.22.559026

Ejemplares similares

Identification of novel modulators of a schistosome transient receptor potential channel targeted by praziquantel
por: Chulkov, Evgeny G., et al.
Publicado: (2021)

Assessment of flukicide efficacy against Fasciola hepatica in sheep in Sweden in the absence of a standardised test
por: Novobilský, Adam, et al.
Publicado: (2016)

Identification of Compounds That Promote Readthrough of Premature Termination Codons in the CFTR
por: Smith, Emery, et al.
Publicado: (2020)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part I)
por: Hou, Shurong, et al.
Publicado: (2021)

Discovery and Optimization of Selective Inhibitors of Meprin α (Part II)
por: Wang, Chao, et al.
Publicado: (2021)

Rescue of mutant gonadotropin-releasing hormone receptor function independent of cognate receptor activity
por: Smith, Emery, et al.
Publicado: (2020)

Molecular Topology for the Discovery of New Broad-Spectrum Antibacterial Drugs
por: Bueso-Bordils, Jose I., et al.
Publicado: (2020)

Discovery and development of safe-in-man broad-spectrum antiviral agents
por: Andersen, Petter I., et al.
Publicado: (2020)

Discovery of 2-Phenylquinolines with Broad-Spectrum Anti-coronavirus Activity
por: Nizi, Maria Giulia, et al.
Publicado: (2022)

Natural variation in the binding pocket of a parasitic flatworm TRPM channel resolves the basis for praziquantel sensitivity
por: Rohr, Claudia M., et al.
Publicado: (2022)

Discovery of Potent Broad Spectrum Antivirals Derived from Marine Actinobacteria
por: Raveh, Avi, et al.
Publicado: (2013)

Drug Screening for Discovery of Broad-spectrum Agents for Soil-transmitted Nematodes
por: Elfawal, Mostafa A., et al.
Publicado: (2019)

Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias
por: Janovick, Jo Ann, et al.
Publicado: (2017)

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate
por: Madoux, Franck, et al.
Publicado: (2016)

Broad‐Spectrum Antidote Discovery by Untangling the Reactivation Mechanism of Nerve‐Agent‐Inhibited Acetylcholinesterase
por: Lindgren, Cecilia, et al.
Publicado: (2022)

Symbionts Commonly Provide Broad Spectrum Resistance to Viruses in Insects: A Comparative Analysis of Wolbachia Strains
por: Martinez, Julien, et al.
Publicado: (2014)

Drug Discovery Targeting COVID-19
por: Spicer, Timothy P.
Publicado: (2020)

Computational approaches for discovery of common immunomodulators in fungal infections: towards broad-spectrum immunotherapeutic interventions
por: Kidane, Yared H, et al.
Publicado: (2013)

Discovery of mercaptopropanamide-substituted aryl tetrazoles as new broad-spectrum metallo-β-lactamase inhibitors
por: Yan, Yu-Hang, et al.
Publicado: (2020)

Broad-Spectrum Antiviral Therapeutics
por: Rider, Todd H., et al.
Publicado: (2011)

Broad Spectrum Bioluminescence: Shine On!
por: Mixter, Phil
Publicado: (2013)

Broad-spectrum antiviral agents
por: Zhu, Jun-Da, et al.
Publicado: (2015)

The broad spectrum of pathogenic autoreactivity
por: Santambrogio, Laura, et al.
Publicado: (2022)

In-Silico Approaches for the Screening and Discovery of Broad-Spectrum Marine Natural Product Antiviral Agents Against Coronaviruses
por: Boswell, Zachary, et al.
Publicado: (2023)

Repurposing of cyclophilin A inhibitors as broad-spectrum antiviral agents
por: Han, Jinhe, et al.
Publicado: (2022)

The anthelmintic drug praziquantel activates a schistosome transient receptor potential channel
por: Park, Sang-Kyu, et al.
Publicado: (2019)

Conveying Discovery to a Broad Audience
por: Knoll, Laura J.
Publicado: (2016)

Elemene sensitizes pancreatic cancer cells to bortezomib by enhancing proteasome inhibition via molecular patch mechanism
por: Hou, Shurong, et al.
Publicado: (2023)

The Anthelmintic Activity of Praziquantel Analogs Correlates with Structure–Activity Relationships at TRPM(PZQ) Orthologs
por: Sprague, Daniel J., et al.
Publicado: (2023)

Coxsackievirus A10 atomic structure facilitating the discovery of a broad-spectrum inhibitor against human enteroviruses
por: Chen, Jinhuan, et al.
Publicado: (2019)

Discovery of New Imidazole Derivatives Containing the 2,4-Dienone Motif with Broad-Spectrum Antifungal and Antibacterial Activity
por: Liu, Chunli, et al.
Publicado: (2014)

Broad-Spectrum Antibacterial Effects of Human Adipose-Derived Stromal Cells
por: Monsarrat, Paul, et al.
Publicado: (2019)

Preparation and Application of Light-Colored Lignin Nanoparticles for Broad-Spectrum Sunscreens
por: Lee, Sang Cheon, et al.
Publicado: (2020)

Passive Broad-Spectrum Influenza Immunoprophylaxis
por: Berry, Cassandra M., et al.
Publicado: (2014)

Light as a Broad-Spectrum Antimicrobial
por: Gwynne, Peter J., et al.
Publicado: (2018)

Azithromycin: The First Broad-spectrum Therapeutic
por: Firth, Anton, et al.
Publicado: (2020)

Cardiac glycosides are broad-spectrum senolytics
por: Guerrero, Ana, et al.
Publicado: (2019)

Modified cyclodextrins as broad-spectrum antivirals
por: Jones, Samuel T., et al.
Publicado: (2020)

Designer broad-spectrum polyimidazolium antibiotics
por: Zhong, Wenbin, et al.
Publicado: (2020)

The broad spectrum of cardiotoxicities from immunotherapies
por: Iengo, Martina, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ndkeoje1k393ednc6j85kstm01