Light-sensitive phosphorylation regulates enzyme activity and filament assembly of human IMPDH1 retinal splice variants

Inosine monophosphate dehydrogenase (IMPDH) is the rate-limiting enzyme in de novo guanosine triphosphate (GTP) synthesis and is controlled by feedback inhibition and allosteric regulation. IMPDH assembles into micron-scale filaments in cells, which desensitizes the enzyme to feedback inhibition by...

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Detalles Bibliográficos
Autores principales: Calise, S. John, O’Neill, Audrey G., Burrell, Anika L., Dickinson, Miles S., Molfino, Josephine, Clarke, Charlie, Quispe, Joel, Sokolov, David, Buey, Rubén M., Kollman, Justin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542554/
https://www.ncbi.nlm.nih.gov/pubmed/37790411
http://dx.doi.org/10.1101/2023.09.21.558867

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542554/
https://www.ncbi.nlm.nih.gov/pubmed/37790411
http://dx.doi.org/10.1101/2023.09.21.558867

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