Elevated PLAUR is observed in the airway epithelium of asthma patients and blocking improves barrier integrity

BACKGROUND: Expression of the urokinase plasminogen activator receptor (uPAR) is elevated in the airway epithelium in asthma; however, the contribution of uPAR to asthma pathogenesis and scope for therapeutic targeting remains unknown. OBJECTIVES: To determine (i) the expression profile of uPAR in c...

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Detalles Bibliográficos
Autores principales: Portelli, Michael A., Bhaker, Sangita, Pang, Vincent, Bates, David O., Johnson, Simon R., Mazar, Andrew P., Shaw, Dominick, Brightling, Christopher, Sayers, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542610/
https://www.ncbi.nlm.nih.gov/pubmed/37876037
http://dx.doi.org/10.1002/clt2.12293

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