Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1

BACKGROUND: To explore the biological effects of CASC11 on aggravating diabetic nephropathy (DN) by regulating FoxO1 (forkhead transcription factor O1). METHODS: Serum levels of CASC11 and FoxO1 in DN patients were detected. The possibility of CASC11 in predicting the onset of DN was analyzed by dep...

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Detalles Bibliográficos
Autores principales: Zhang, Yun, Shi, Shuhan, Lin, Changda, Che, Lishuang, Li, Yuangen, Zeng, Quanzuan, Lin, Weiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Society of Medical Biochemists of Serbia, Belgrade 2023
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542706/
https://www.ncbi.nlm.nih.gov/pubmed/37790209
http://dx.doi.org/10.5937/jomb0-42345
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author Zhang, Yun
Shi, Shuhan
Lin, Changda
Che, Lishuang
Li, Yuangen
Zeng, Quanzuan
Lin, Weiyuan
author_facet Zhang, Yun
Shi, Shuhan
Lin, Changda
Che, Lishuang
Li, Yuangen
Zeng, Quanzuan
Lin, Weiyuan
author_sort Zhang, Yun
collection PubMed
description BACKGROUND: To explore the biological effects of CASC11 on aggravating diabetic nephropathy (DN) by regulating FoxO1 (forkhead transcription factor O1). METHODS: Serum levels of CASC11 and FoxO1 in DN patients were detected. The possibility of CASC11 in predicting the onset of DN was analyzed by depicting ROC curves. Correlation between CASC11 and FoxO1 was evaluated by Pearson correlation test. After intervening CASC11 and FoxO1 levels, we found that changes in proliferative and migratory abilities in high glucose (HG)induced kidney mesangial cells were determined respectively. Protein levels of TGF-β1 and Smads regulated by both CASC11 and FoxO1 were examined by Western blot.
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spelling pubmed-105427062023-10-03 Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1 Zhang, Yun Shi, Shuhan Lin, Changda Che, Lishuang Li, Yuangen Zeng, Quanzuan Lin, Weiyuan J Med Biochem Original Paper BACKGROUND: To explore the biological effects of CASC11 on aggravating diabetic nephropathy (DN) by regulating FoxO1 (forkhead transcription factor O1). METHODS: Serum levels of CASC11 and FoxO1 in DN patients were detected. The possibility of CASC11 in predicting the onset of DN was analyzed by depicting ROC curves. Correlation between CASC11 and FoxO1 was evaluated by Pearson correlation test. After intervening CASC11 and FoxO1 levels, we found that changes in proliferative and migratory abilities in high glucose (HG)induced kidney mesangial cells were determined respectively. Protein levels of TGF-β1 and Smads regulated by both CASC11 and FoxO1 were examined by Western blot. Society of Medical Biochemists of Serbia, Belgrade 2023-08-25 2023-08-25 /pmc/articles/PMC10542706/ /pubmed/37790209 http://dx.doi.org/10.5937/jomb0-42345 Text en 2023 Yun Zhang, Shuhan Shi, Changda Lin, Lishuang Che, Yuangen Li, Quanzuan Zeng, Weiyuan Lin, published by CEON/CEES https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License.
spellingShingle Original Paper
Zhang, Yun
Shi, Shuhan
Lin, Changda
Che, Lishuang
Li, Yuangen
Zeng, Quanzuan
Lin, Weiyuan
Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1
title Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1
title_full Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1
title_fullStr Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1
title_full_unstemmed Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1
title_short Lncrna CASC11 aggravates diabetic nephropathy via targeting FoxO1
title_sort lncrna casc11 aggravates diabetic nephropathy via targeting foxo1
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542706/
https://www.ncbi.nlm.nih.gov/pubmed/37790209
http://dx.doi.org/10.5937/jomb0-42345
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