John squire and endothelial glycocalyx structure: an unfinished story

John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his...

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Detalles Bibliográficos
Autores principales: Arkill, Kenton P., Michel, C. Charles, Rider, Elizabeth V. M., Wood, Elise A., Small, Mathew O., Brown, Jennifer L. E., Kinnaird, Abigail L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542707/
https://www.ncbi.nlm.nih.gov/pubmed/36260209
http://dx.doi.org/10.1007/s10974-022-09629-x
Descripción
Sumario:John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glycosaminoglycans fibres per syndecan core protein, only achieved in the endothelium by dimerization. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10974-022-09629-x.

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