John squire and endothelial glycocalyx structure: an unfinished story

John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his...

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Autores principales: Arkill, Kenton P., Michel, C. Charles, Rider, Elizabeth V. M., Wood, Elise A., Small, Mathew O., Brown, Jennifer L. E., Kinnaird, Abigail L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542707/
https://www.ncbi.nlm.nih.gov/pubmed/36260209
http://dx.doi.org/10.1007/s10974-022-09629-x
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author Arkill, Kenton P.
Michel, C. Charles
Rider, Elizabeth V. M.
Wood, Elise A.
Small, Mathew O.
Brown, Jennifer L. E.
Kinnaird, Abigail L.
author_facet Arkill, Kenton P.
Michel, C. Charles
Rider, Elizabeth V. M.
Wood, Elise A.
Small, Mathew O.
Brown, Jennifer L. E.
Kinnaird, Abigail L.
author_sort Arkill, Kenton P.
collection PubMed
description John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glycosaminoglycans fibres per syndecan core protein, only achieved in the endothelium by dimerization. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10974-022-09629-x.
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spelling pubmed-105427072023-10-03 John squire and endothelial glycocalyx structure: an unfinished story Arkill, Kenton P. Michel, C. Charles Rider, Elizabeth V. M. Wood, Elise A. Small, Mathew O. Brown, Jennifer L. E. Kinnaird, Abigail L. J Muscle Res Cell Motil Review John Squire did not only produce leading works in the muscle field, he also significantly contributed to the vascular permeability field by ultrastructural analysis of the endothelial glycocalyx. Presented here is a review of his involvement in the field by his main collaborator C.C. Michel and his last postdoctoral researcher KP Arkill. We end on a reinterpretation of his work that arguably links to our current understanding of endothelial glycocalyx structure and composition predicting 6 glycosaminoglycans fibres per syndecan core protein, only achieved in the endothelium by dimerization. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10974-022-09629-x. Springer International Publishing 2022-10-19 2023 /pmc/articles/PMC10542707/ /pubmed/36260209 http://dx.doi.org/10.1007/s10974-022-09629-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review
Arkill, Kenton P.
Michel, C. Charles
Rider, Elizabeth V. M.
Wood, Elise A.
Small, Mathew O.
Brown, Jennifer L. E.
Kinnaird, Abigail L.
John squire and endothelial glycocalyx structure: an unfinished story
title John squire and endothelial glycocalyx structure: an unfinished story
title_full John squire and endothelial glycocalyx structure: an unfinished story
title_fullStr John squire and endothelial glycocalyx structure: an unfinished story
title_full_unstemmed John squire and endothelial glycocalyx structure: an unfinished story
title_short John squire and endothelial glycocalyx structure: an unfinished story
title_sort john squire and endothelial glycocalyx structure: an unfinished story
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542707/
https://www.ncbi.nlm.nih.gov/pubmed/36260209
http://dx.doi.org/10.1007/s10974-022-09629-x
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