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IFNɣ but not IFNα increases recognition of insulin defective ribosomal product-derived antigen to amplify islet autoimmunity

AIMS/HYPOTHESIS: The inflammatory milieu characteristic of insulitis affects translation fidelity and generates defective ribosomal products (DRiPs) that participate in autoimmune beta cell destruction in type 1 diabetes. Here, we studied the role of early innate cytokines (IFNα) and late immune ada...

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Detalles Bibliográficos
Autores principales:	Thomaidou, Sofia, Munoz Garcia, Amadeo, de Lange, Sabine, Gan, Jin, van der Slik, Arno R., Hoeben, Rob C., Roep, Bart O., Carlotti, Françoise, Zaldumbide, Arnaud
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542729/ https://www.ncbi.nlm.nih.gov/pubmed/37581620 http://dx.doi.org/10.1007/s00125-023-05991-8

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