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SERCA2 regulates proinsulin processing and processing enzyme maturation in pancreatic beta cells

AIMS/HYPOTHESIS: Increased circulating levels of incompletely processed insulin (i.e. proinsulin) are observed clinically in type 1 and type 2 diabetes. Previous studies have suggested that Ca(2+) signalling within beta cells regulates insulin processing and secretion; however, the mechanisms that l...

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Detalles Bibliográficos
Autores principales:	Iida, Hitoshi, Kono, Tatsuyoshi, Lee, Chih-Chun, Krishnan, Preethi, Arvin, Matthew C., Weaver, Staci A., Jarvela, Timothy S., Branco, Renato C. S., McLaughlin, Madeline R., Bone, Robert N., Tong, Xin, Arvan, Peter, Lindberg, Iris, Evans-Molina, Carmella
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2023
Materias:	Extended Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542743/ https://www.ncbi.nlm.nih.gov/pubmed/37537395 http://dx.doi.org/10.1007/s00125-023-05979-4

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