IFNγ-Stat1 axis drives aging-associated loss of intestinal tissue homeostasis and regeneration

The influence of aging on intestinal stem cells and their niche can explain underlying causes for perturbation in their function observed during aging. Molecular mechanisms for such a decrease in the functionality of intestinal stem cells during aging remain largely undetermined. Using transcriptome...

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Detalles Bibliográficos
Autores principales: Omrani, Omid, Krepelova, Anna, Rasa, Seyed Mohammad Mahdi, Sirvinskas, Dovydas, Lu, Jing, Annunziata, Francesco, Garside, George, Bajwa, Seerat, Reinhardt, Susanne, Adam, Lisa, Käppel, Sandra, Ducano, Nadia, Donna, Daniela, Ori, Alessandro, Oliviero, Salvatore, Rudolph, Karl Lenhard, Neri, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542816/
https://www.ncbi.nlm.nih.gov/pubmed/37777550
http://dx.doi.org/10.1038/s41467-023-41683-y

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