Inactivation of p53 provides a competitive advantage to del(5q) myelodysplastic syndrome hematopoietic stem cells during inflammation

Inflammation is associated with the pathogenesis of myelodysplastic syndromes (MDS) and emerging evidence suggests that MDS hematopoietic stem and progenitor cells (HSPC) exhibit an altered response to inflammation. Deletion of chromosome 5 (del(5q)) is the most common chromosomal abnormality in MDS...

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Detalles Bibliográficos
Autores principales: Muto, Tomoya, Walker, Callum S., Agarwal, Puneet, Vick, Eric, Sampson, Avery, Choi, Kwangmin, Niederkorn, Madeline, Ishikawa, Chiharu, Hueneman, Kathleen, Varney, Melinda, Starczynowski, Daniel T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2023
Materias:
Article - Myelodysplastic Syndromes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542836/
https://www.ncbi.nlm.nih.gov/pubmed/37102608
http://dx.doi.org/10.3324/haematol.2022.282349

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