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Serum Vitamin D Status in Older Adults: A Cohort Study

BACKGROUND: Vitamin D is best known as a key regulator of bone metabolism and calcium and phosphate homeostasis. This study aimed to assess the effect of different factors on the five-year changes in serum vitamin D concentration among older adults. METHODS: This cohort study was conducted on adults...

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Autores principales: Mouodi, Simin, Delbari, Sajedeh, Hosseini, Seyed Reza, Ghadimi, Reza, Bijani, Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shiraz University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542922/
https://www.ncbi.nlm.nih.gov/pubmed/37791339
http://dx.doi.org/10.30476/IJMS.2022.94269.2550
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author Mouodi, Simin
Delbari, Sajedeh
Hosseini, Seyed Reza
Ghadimi, Reza
Bijani, Ali
author_facet Mouodi, Simin
Delbari, Sajedeh
Hosseini, Seyed Reza
Ghadimi, Reza
Bijani, Ali
author_sort Mouodi, Simin
collection PubMed
description BACKGROUND: Vitamin D is best known as a key regulator of bone metabolism and calcium and phosphate homeostasis. This study aimed to assess the effect of different factors on the five-year changes in serum vitamin D concentration among older adults. METHODS: This cohort study was conducted on adults aged ≥60 years living in Amirkola, in the North of Iran, from 2012 to 2017. Serum 25-hydroxyvitamin D (25-OH vitamin D) concentrations of <20, 20-29.99, and ≥30 ng/mL, respectively, were used to designate vitamin D deficiency, insufficiency, and sufficiency. Any variation between the second and baseline values of the 25-OH vitamin D concentration was reported as a five-year difference. Data were analyzed using SPSS version 17.0, and Chi square, t test, one-way ANOVA, and Tukey HSD post hoc tests were employed. P values less than 0.05 were considered statistically significant. RESULTS: The mean serum concentration of 25-OH vitamin D at baseline and follow-up examination in 1011 individuals was 34.68±33.18 and 23.88±14.91, respectively (P<0.001). Following a five-year follow-up, vitamin D deficiency, insufficiency, and sufficiency were found in 452 (44.7%), 334 (33.0%), and 225 (22.3%) cases, respectively. The reduction in serum 25-OH vitamin D concentration after five years was significantly influenced by the administration of vitamin D (P=0.013) and calcium (P=0.007) supplements, serum profile of parathyroid hormone (PTH) (P=0.010), calcium (P=0.021), and phosphorous (P=0.021). However, age, sex, body mass index, metabolic syndrome, and physical activity had no significant impact (P>0.05). CONCLUSION: Regardless of age, sex, body mass index, metabolic syndrome, or physical activity, the mean serum concentration of vitamin D decreased over a five-year follow-up.
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spelling pubmed-105429222023-10-03 Serum Vitamin D Status in Older Adults: A Cohort Study Mouodi, Simin Delbari, Sajedeh Hosseini, Seyed Reza Ghadimi, Reza Bijani, Ali Iran J Med Sci Original Article BACKGROUND: Vitamin D is best known as a key regulator of bone metabolism and calcium and phosphate homeostasis. This study aimed to assess the effect of different factors on the five-year changes in serum vitamin D concentration among older adults. METHODS: This cohort study was conducted on adults aged ≥60 years living in Amirkola, in the North of Iran, from 2012 to 2017. Serum 25-hydroxyvitamin D (25-OH vitamin D) concentrations of <20, 20-29.99, and ≥30 ng/mL, respectively, were used to designate vitamin D deficiency, insufficiency, and sufficiency. Any variation between the second and baseline values of the 25-OH vitamin D concentration was reported as a five-year difference. Data were analyzed using SPSS version 17.0, and Chi square, t test, one-way ANOVA, and Tukey HSD post hoc tests were employed. P values less than 0.05 were considered statistically significant. RESULTS: The mean serum concentration of 25-OH vitamin D at baseline and follow-up examination in 1011 individuals was 34.68±33.18 and 23.88±14.91, respectively (P<0.001). Following a five-year follow-up, vitamin D deficiency, insufficiency, and sufficiency were found in 452 (44.7%), 334 (33.0%), and 225 (22.3%) cases, respectively. The reduction in serum 25-OH vitamin D concentration after five years was significantly influenced by the administration of vitamin D (P=0.013) and calcium (P=0.007) supplements, serum profile of parathyroid hormone (PTH) (P=0.010), calcium (P=0.021), and phosphorous (P=0.021). However, age, sex, body mass index, metabolic syndrome, and physical activity had no significant impact (P>0.05). CONCLUSION: Regardless of age, sex, body mass index, metabolic syndrome, or physical activity, the mean serum concentration of vitamin D decreased over a five-year follow-up. Shiraz University of Medical Sciences 2023-05 /pmc/articles/PMC10542922/ /pubmed/37791339 http://dx.doi.org/10.30476/IJMS.2022.94269.2550 Text en Copyright: © Iranian Journal of Medical Sciences https://creativecommons.org/licenses/by-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NoDerivatives 4.0 International License. This license allows reusers to copy and distribute the material in any medium or format in unadapted form only, and only so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Original Article
Mouodi, Simin
Delbari, Sajedeh
Hosseini, Seyed Reza
Ghadimi, Reza
Bijani, Ali
Serum Vitamin D Status in Older Adults: A Cohort Study
title Serum Vitamin D Status in Older Adults: A Cohort Study
title_full Serum Vitamin D Status in Older Adults: A Cohort Study
title_fullStr Serum Vitamin D Status in Older Adults: A Cohort Study
title_full_unstemmed Serum Vitamin D Status in Older Adults: A Cohort Study
title_short Serum Vitamin D Status in Older Adults: A Cohort Study
title_sort serum vitamin d status in older adults: a cohort study
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10542922/
https://www.ncbi.nlm.nih.gov/pubmed/37791339
http://dx.doi.org/10.30476/IJMS.2022.94269.2550
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