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Impact of lesion location and functional parameters on vision-related quality of life in geographic atrophy secondary to AMD

BACKGROUND/AIMS: The primary objective was to determine how structural and functional parameters influence the vision-related quality of life (VRQoL) in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). METHODS: This prospective, non-interventional, natural-h...

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Autores principales: Künzel, Sandrine H., Broadbent, Eliza, Möller, Philipp T, Lindner, Moritz, Goerdt, Lukas, Czauderna, Joanna, Schmitz-Valckenberg, Steffen, Holz, Frank G, Pfau, Maximilian, Fleckenstein, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543058/
https://www.ncbi.nlm.nih.gov/pubmed/37790350
http://dx.doi.org/10.1101/2023.09.22.23295946
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author Künzel, Sandrine H.
Broadbent, Eliza
Möller, Philipp T
Lindner, Moritz
Goerdt, Lukas
Czauderna, Joanna
Schmitz-Valckenberg, Steffen
Holz, Frank G
Pfau, Maximilian
Fleckenstein, Monika
author_facet Künzel, Sandrine H.
Broadbent, Eliza
Möller, Philipp T
Lindner, Moritz
Goerdt, Lukas
Czauderna, Joanna
Schmitz-Valckenberg, Steffen
Holz, Frank G
Pfau, Maximilian
Fleckenstein, Monika
author_sort Künzel, Sandrine H.
collection PubMed
description BACKGROUND/AIMS: The primary objective was to determine how structural and functional parameters influence the vision-related quality of life (VRQoL) in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). METHODS: This prospective, non-interventional, natural-history ‘Directional Spread in Geographic-Atrophy’ study was conducted at the University Eye Hospital in Bonn, enrolling 82 patients with bilateral GA. Parameters such as GA location (assessed by the Early Treatment Diabetic Retinopathy Study grid), best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), reading acuity, and speed were examined. The association between these parameters and VRQoL, as gauged using the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25), was analyzed through least absolute shrinkage and selection operator with linear mixed-effects models. RESULTS: The average total GA area observed was 2.9 ± 1.2 mm(2) (better eye) and 3.1 ± 1.3 mm(2) (worse eye). The VRQoL scores for distance and near activities were most associated with the inner lower and inner left subfields of the better eye. For foveal-sparing patients, the LLVA of the better eye was the predominant determinate impacting all VRQoL scales. CONCLUSION: GA location, specifically the inner lower and inner left subfields of the better eye, has a notable effect on VRQoL in GA patients. LLVA stands out as especially vital in foveal-sparing patients, underscoring the importance for clinicians to incorporate considerations of GA location and functional parameters into their risk-benefit assessments for emerging treatments.
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spelling pubmed-105430582023-10-03 Impact of lesion location and functional parameters on vision-related quality of life in geographic atrophy secondary to AMD Künzel, Sandrine H. Broadbent, Eliza Möller, Philipp T Lindner, Moritz Goerdt, Lukas Czauderna, Joanna Schmitz-Valckenberg, Steffen Holz, Frank G Pfau, Maximilian Fleckenstein, Monika medRxiv Article BACKGROUND/AIMS: The primary objective was to determine how structural and functional parameters influence the vision-related quality of life (VRQoL) in patients with geographic atrophy (GA) secondary to age-related macular degeneration (AMD). METHODS: This prospective, non-interventional, natural-history ‘Directional Spread in Geographic-Atrophy’ study was conducted at the University Eye Hospital in Bonn, enrolling 82 patients with bilateral GA. Parameters such as GA location (assessed by the Early Treatment Diabetic Retinopathy Study grid), best-corrected visual acuity (BCVA), low-luminance visual acuity (LLVA), reading acuity, and speed were examined. The association between these parameters and VRQoL, as gauged using the National Eye Institute Visual Function Questionnaire 25 (NEI VFQ-25), was analyzed through least absolute shrinkage and selection operator with linear mixed-effects models. RESULTS: The average total GA area observed was 2.9 ± 1.2 mm(2) (better eye) and 3.1 ± 1.3 mm(2) (worse eye). The VRQoL scores for distance and near activities were most associated with the inner lower and inner left subfields of the better eye. For foveal-sparing patients, the LLVA of the better eye was the predominant determinate impacting all VRQoL scales. CONCLUSION: GA location, specifically the inner lower and inner left subfields of the better eye, has a notable effect on VRQoL in GA patients. LLVA stands out as especially vital in foveal-sparing patients, underscoring the importance for clinicians to incorporate considerations of GA location and functional parameters into their risk-benefit assessments for emerging treatments. Cold Spring Harbor Laboratory 2023-09-23 /pmc/articles/PMC10543058/ /pubmed/37790350 http://dx.doi.org/10.1101/2023.09.22.23295946 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which allows reusers to copy and distribute the material in any medium or format in unadapted form only, for noncommercial purposes only, and only so long as attribution is given to the creator.
spellingShingle Article
Künzel, Sandrine H.
Broadbent, Eliza
Möller, Philipp T
Lindner, Moritz
Goerdt, Lukas
Czauderna, Joanna
Schmitz-Valckenberg, Steffen
Holz, Frank G
Pfau, Maximilian
Fleckenstein, Monika
Impact of lesion location and functional parameters on vision-related quality of life in geographic atrophy secondary to AMD
title Impact of lesion location and functional parameters on vision-related quality of life in geographic atrophy secondary to AMD
title_full Impact of lesion location and functional parameters on vision-related quality of life in geographic atrophy secondary to AMD
title_fullStr Impact of lesion location and functional parameters on vision-related quality of life in geographic atrophy secondary to AMD
title_full_unstemmed Impact of lesion location and functional parameters on vision-related quality of life in geographic atrophy secondary to AMD
title_short Impact of lesion location and functional parameters on vision-related quality of life in geographic atrophy secondary to AMD
title_sort impact of lesion location and functional parameters on vision-related quality of life in geographic atrophy secondary to amd
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543058/
https://www.ncbi.nlm.nih.gov/pubmed/37790350
http://dx.doi.org/10.1101/2023.09.22.23295946
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