Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review

Statins are the first line of treatment for hyperlipidaemia. Along with lowering lipids, it also lowers mortality and cardiovascular risk. Statins play a major role in maintaining the homeostasis of the oral cavity via a number of different mechanisms. It includes regeneration of dentin and pulp by...

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Autores principales: Kabra, Sakshi, Thosar, Nilima R, Malviya, Nishi S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543113/
https://www.ncbi.nlm.nih.gov/pubmed/37791218
http://dx.doi.org/10.7759/cureus.44411
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author Kabra, Sakshi
Thosar, Nilima R
Malviya, Nishi S
author_facet Kabra, Sakshi
Thosar, Nilima R
Malviya, Nishi S
author_sort Kabra, Sakshi
collection PubMed
description Statins are the first line of treatment for hyperlipidaemia. Along with lowering lipids, it also lowers mortality and cardiovascular risk. Statins play a major role in maintaining the homeostasis of the oral cavity via a number of different mechanisms. It includes regeneration of dentin and pulp by differentiation and increased development of mineralized tissue via the bone morphogenetic proteins (BMP)-2 Pathway. It shows effective bone health by leading to osteogenic differentiation mesenchymal stem cells, by facilitating epithelization process in wound healing, anti-inflammatory, antioxidant, antimicrobial, antiviral, and fungicidal properties. To the finest of the information we have, there have been very few comprehensive studies that have investigated the effects of statin drugs on various aspects of dental and oral health. As a result, the main objective of this review was to examine the effect of statins on oral health applications. According to the findings of our extensive review, statins have noteworthy and promising effects on several aspects of oral health, including dental pulp cells, chronic periodontitis, alveolar bone loss, orthodontic tooth movement, and so on. Nevertheless, it is concluded that local or even systemic administration of simvastatin should be regarded as an innovative, easily accessible, and safe therapeutic agent that has a significant impact on enhancing the oral health.
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spelling pubmed-105431132023-10-03 Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review Kabra, Sakshi Thosar, Nilima R Malviya, Nishi S Cureus Pediatrics Statins are the first line of treatment for hyperlipidaemia. Along with lowering lipids, it also lowers mortality and cardiovascular risk. Statins play a major role in maintaining the homeostasis of the oral cavity via a number of different mechanisms. It includes regeneration of dentin and pulp by differentiation and increased development of mineralized tissue via the bone morphogenetic proteins (BMP)-2 Pathway. It shows effective bone health by leading to osteogenic differentiation mesenchymal stem cells, by facilitating epithelization process in wound healing, anti-inflammatory, antioxidant, antimicrobial, antiviral, and fungicidal properties. To the finest of the information we have, there have been very few comprehensive studies that have investigated the effects of statin drugs on various aspects of dental and oral health. As a result, the main objective of this review was to examine the effect of statins on oral health applications. According to the findings of our extensive review, statins have noteworthy and promising effects on several aspects of oral health, including dental pulp cells, chronic periodontitis, alveolar bone loss, orthodontic tooth movement, and so on. Nevertheless, it is concluded that local or even systemic administration of simvastatin should be regarded as an innovative, easily accessible, and safe therapeutic agent that has a significant impact on enhancing the oral health. Cureus 2023-08-30 /pmc/articles/PMC10543113/ /pubmed/37791218 http://dx.doi.org/10.7759/cureus.44411 Text en Copyright © 2023, Kabra et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Kabra, Sakshi
Thosar, Nilima R
Malviya, Nishi S
Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review
title Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review
title_full Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review
title_fullStr Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review
title_full_unstemmed Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review
title_short Exploring the Synergistic Effect of Simvastatin in Oral Health Applications: A Literature Review
title_sort exploring the synergistic effect of simvastatin in oral health applications: a literature review
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543113/
https://www.ncbi.nlm.nih.gov/pubmed/37791218
http://dx.doi.org/10.7759/cureus.44411
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