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Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder

Functional connectivity (FC) derived from resting‐state functional magnetic resonance imaging has been widely applied to guide precise repetitive transcranial magnetic stimulation (rTMS). The left, right, and bilateral dorsolateral prefrontal cortices (DLPFC) have been used as rTMS treatment target...

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Autores principales: Jin, Jing, Wang, Xiu‐Qin, Yang, Xue, Zhao, Na, Feng, Zi‐Jian, Zang, Yu‐Feng, Yuan, Li‐Xia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543114/
https://www.ncbi.nlm.nih.gov/pubmed/37694907
http://dx.doi.org/10.1002/hbm.26455
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author Jin, Jing
Wang, Xiu‐Qin
Yang, Xue
Zhao, Na
Feng, Zi‐Jian
Zang, Yu‐Feng
Yuan, Li‐Xia
author_facet Jin, Jing
Wang, Xiu‐Qin
Yang, Xue
Zhao, Na
Feng, Zi‐Jian
Zang, Yu‐Feng
Yuan, Li‐Xia
author_sort Jin, Jing
collection PubMed
description Functional connectivity (FC) derived from resting‐state functional magnetic resonance imaging has been widely applied to guide precise repetitive transcranial magnetic stimulation (rTMS). The left, right, and bilateral dorsolateral prefrontal cortices (DLPFC) have been used as rTMS treatment target regions for autism spectrum disorder (ASD), albeit with moderate efficacy. Thus, we aimed to develop an individualized localization method for rTMS treatment of ASD. We included 266 male ASDs and 297 male typically‐developed controls (TDCs) from the Autism Brain Imaging Data Exchange Dataset. The nucleus accumbens (NAc) was regarded as a promising effective region, which was used as a seed and individualized peak FC strength in the DLPFC was compared between ASD and TDC. Correlation analysis was conducted between individualized peak FC strength and symptoms in ASD. We also investigated the spatial distribution of individualized peak FC locations in the DLPFC and conducted voxel‐wise analysis to compare NAc‐based FC between the two groups. ASD showed stronger peak FC in the right DLPFC related to TDC (Cohen's d = −.19, 95% CI: −0.36 to −0.03, t = −2.30, p = .02). Moreover, negative correlation was found between the peak FC strength in the right DLPFC and Autism Diagnostic Observation Schedule (ADOS) scores, which assessed both the social communication and interaction (r = −.147, p = .04, uncorrected significant), and stereotyped behaviors and restricted interests (r = −.198, p = .02, corrected significant). Peak FC locations varied substantially across participants. No significant differences in NAc‐based FC in the DLPFC were found in the voxel‐wise comparison. Our study supports the use of individualized peak FC‐guided precise rTMS treatment of male ASD. Moreover, stimulating the right DLPFC might alleviate core symptoms of ASD.
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spelling pubmed-105431142023-10-03 Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder Jin, Jing Wang, Xiu‐Qin Yang, Xue Zhao, Na Feng, Zi‐Jian Zang, Yu‐Feng Yuan, Li‐Xia Hum Brain Mapp Research Articles Functional connectivity (FC) derived from resting‐state functional magnetic resonance imaging has been widely applied to guide precise repetitive transcranial magnetic stimulation (rTMS). The left, right, and bilateral dorsolateral prefrontal cortices (DLPFC) have been used as rTMS treatment target regions for autism spectrum disorder (ASD), albeit with moderate efficacy. Thus, we aimed to develop an individualized localization method for rTMS treatment of ASD. We included 266 male ASDs and 297 male typically‐developed controls (TDCs) from the Autism Brain Imaging Data Exchange Dataset. The nucleus accumbens (NAc) was regarded as a promising effective region, which was used as a seed and individualized peak FC strength in the DLPFC was compared between ASD and TDC. Correlation analysis was conducted between individualized peak FC strength and symptoms in ASD. We also investigated the spatial distribution of individualized peak FC locations in the DLPFC and conducted voxel‐wise analysis to compare NAc‐based FC between the two groups. ASD showed stronger peak FC in the right DLPFC related to TDC (Cohen's d = −.19, 95% CI: −0.36 to −0.03, t = −2.30, p = .02). Moreover, negative correlation was found between the peak FC strength in the right DLPFC and Autism Diagnostic Observation Schedule (ADOS) scores, which assessed both the social communication and interaction (r = −.147, p = .04, uncorrected significant), and stereotyped behaviors and restricted interests (r = −.198, p = .02, corrected significant). Peak FC locations varied substantially across participants. No significant differences in NAc‐based FC in the DLPFC were found in the voxel‐wise comparison. Our study supports the use of individualized peak FC‐guided precise rTMS treatment of male ASD. Moreover, stimulating the right DLPFC might alleviate core symptoms of ASD. John Wiley & Sons, Inc. 2023-09-11 /pmc/articles/PMC10543114/ /pubmed/37694907 http://dx.doi.org/10.1002/hbm.26455 Text en © 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC. https://creativecommons.org/licenses/by-nc/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Research Articles
Jin, Jing
Wang, Xiu‐Qin
Yang, Xue
Zhao, Na
Feng, Zi‐Jian
Zang, Yu‐Feng
Yuan, Li‐Xia
Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder
title Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder
title_full Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder
title_fullStr Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder
title_full_unstemmed Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder
title_short Abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder
title_sort abnormal individualized peak functional connectivity toward potential repetitive transcranial magnetic stimulation treatment of autism spectrum disorder
topic Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543114/
https://www.ncbi.nlm.nih.gov/pubmed/37694907
http://dx.doi.org/10.1002/hbm.26455
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