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Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy
2-Methacryloyloxyethyl phosphorylcholine (MPC) zwitterions were modified onto self-made graphene oxide (GO) through the atom transfer radical polymerization method. The chemical structures of the products were verified using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, nuclear...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543201/ https://www.ncbi.nlm.nih.gov/pubmed/37790105 http://dx.doi.org/10.1039/d3ra04987f |
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author | Cui, Jia Zhang, Ziyi Zhong, Han Zhang, Tao |
author_facet | Cui, Jia Zhang, Ziyi Zhong, Han Zhang, Tao |
author_sort | Cui, Jia |
collection | PubMed |
description | 2-Methacryloyloxyethyl phosphorylcholine (MPC) zwitterions were modified onto self-made graphene oxide (GO) through the atom transfer radical polymerization method. The chemical structures of the products were verified using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, nuclear magnetic resonance spectroscopy (NMR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), etc. It was found that the modified GO (GO-PCn) is well dispersed in water with an average hydrodynamic diameter of about 170 nm. By utilizing the 2D planar structure of this modified graphene, the irinotecan@GO-PCn composite can be loaded with about 20% of irinotecan via π–π stacking interaction and exhibit pH-sensitive drug release performance, releasing faster in the acidic environment. The in vitro cytotoxicity assessments confirmed that GO-PCn composed of phosphorylcholine moiety represented low cytotoxicity and acted as a certain effect on reducing the acute toxicity of irinotecan, which established a foundation for further studies of the system in oncology therapy. |
format | Online Article Text |
id | pubmed-10543201 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Royal Society of Chemistry |
record_format | MEDLINE/PubMed |
spelling | pubmed-105432012023-10-03 Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy Cui, Jia Zhang, Ziyi Zhong, Han Zhang, Tao RSC Adv Chemistry 2-Methacryloyloxyethyl phosphorylcholine (MPC) zwitterions were modified onto self-made graphene oxide (GO) through the atom transfer radical polymerization method. The chemical structures of the products were verified using Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, nuclear magnetic resonance spectroscopy (NMR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), etc. It was found that the modified GO (GO-PCn) is well dispersed in water with an average hydrodynamic diameter of about 170 nm. By utilizing the 2D planar structure of this modified graphene, the irinotecan@GO-PCn composite can be loaded with about 20% of irinotecan via π–π stacking interaction and exhibit pH-sensitive drug release performance, releasing faster in the acidic environment. The in vitro cytotoxicity assessments confirmed that GO-PCn composed of phosphorylcholine moiety represented low cytotoxicity and acted as a certain effect on reducing the acute toxicity of irinotecan, which established a foundation for further studies of the system in oncology therapy. The Royal Society of Chemistry 2023-10-02 /pmc/articles/PMC10543201/ /pubmed/37790105 http://dx.doi.org/10.1039/d3ra04987f Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/ |
spellingShingle | Chemistry Cui, Jia Zhang, Ziyi Zhong, Han Zhang, Tao Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy |
title | Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy |
title_full | Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy |
title_fullStr | Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy |
title_full_unstemmed | Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy |
title_short | Phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy |
title_sort | phosphorylcholine-grafted graphene oxide loaded with irinotecan for potential oncology therapy |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543201/ https://www.ncbi.nlm.nih.gov/pubmed/37790105 http://dx.doi.org/10.1039/d3ra04987f |
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