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The Safety and Efficacy of Systemic Delivery of a New Liver-de-targeted TGFβ Signaling Inhibiting Adenovirus in an Immunocompetent Triple Negative Mouse Mammary Tumor Model

Aberrant TGFβ signaling is linked to metastasis and tumor immune escape of many cancers including metastatic triple negative breast cancer (mTNBC). Previously, we have found that oncolytic adenoviruses expressing a TGFβ signaling inhibitory protein (sTGFβRIIFc) induced immune activation in a mouse T...

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Detalles Bibliográficos
Autores principales:	Xu, Weidong, Shin, Soon Cheon, Vickman, Renee, Filimon, Beniamin, Yang, Yuefeng, Hu, Zebin, Mangold, Kathy, Prabhakar, Bellur, Schreiber, Hans
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Journal Experts 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543255/ https://www.ncbi.nlm.nih.gov/pubmed/37790556 http://dx.doi.org/10.21203/rs.3.rs-3317863/v1

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