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NADH elevation during chronic hypoxia leads to VHL-mediated HIF-1α degradation via SIRT1 inhibition

BACKGROUND: Under conditions of hypoxia, cancer cells with hypoxia inducible factor-1α (HIF-1α) from heterogeneous tumor cells show greater aggression and progression in an effort to compensate for harsh environmental conditions. Extensive study on the stability of HIF-1α under conditions of acute h...

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Detalles Bibliográficos
Autores principales:	Joo, Hyun-Yoo, Jung, Jin Kyu, Kim, Mi-Yeon, Woo, Seon Rang, Jeong, Jae Min, Park, Eun-Ran, Kim, Yong-Min, Park, Joong-Jean, Kim, Joon, Yun, Miyong, Shin, Hyun-Jin, Lee, Kee-Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543270/ https://www.ncbi.nlm.nih.gov/pubmed/37777750 http://dx.doi.org/10.1186/s13578-023-01130-3

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