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The oxidative stress response of Streptococcus pneumoniae: its contribution to both extracellular and intracellular survival

Streptococcus pneumoniae is a gram-positive, aerotolerant bacterium that naturally colonizes the human nasopharynx, but also causes invasive infections and is a major cause of morbidity and mortality worldwide. This pathogen produces high levels of H(2)O(2) to eliminate other microorganisms that bel...

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Autores principales: Hernandez-Morfa, Mirelys, Olivero, Nadia B., Zappia, Victoria E., Piñas, German E., Reinoso-Vizcaino, Nicolas M., Cian, Melina B., Nuñez-Fernandez, Mariana, Cortes, Paulo R., Echenique, Jose
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543277/
https://www.ncbi.nlm.nih.gov/pubmed/37789846
http://dx.doi.org/10.3389/fmicb.2023.1269843
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author Hernandez-Morfa, Mirelys
Olivero, Nadia B.
Zappia, Victoria E.
Piñas, German E.
Reinoso-Vizcaino, Nicolas M.
Cian, Melina B.
Nuñez-Fernandez, Mariana
Cortes, Paulo R.
Echenique, Jose
author_facet Hernandez-Morfa, Mirelys
Olivero, Nadia B.
Zappia, Victoria E.
Piñas, German E.
Reinoso-Vizcaino, Nicolas M.
Cian, Melina B.
Nuñez-Fernandez, Mariana
Cortes, Paulo R.
Echenique, Jose
author_sort Hernandez-Morfa, Mirelys
collection PubMed
description Streptococcus pneumoniae is a gram-positive, aerotolerant bacterium that naturally colonizes the human nasopharynx, but also causes invasive infections and is a major cause of morbidity and mortality worldwide. This pathogen produces high levels of H(2)O(2) to eliminate other microorganisms that belong to the microbiota of the respiratory tract. However, it also induces an oxidative stress response to survive under this stressful condition. Furthermore, this self-defense mechanism is advantageous in tolerating oxidative stress imposed by the host’s immune response. This review provides a comprehensive overview of the strategies employed by the pneumococcus to survive oxidative stress. These strategies encompass the utilization of H(2)O(2) scavengers and thioredoxins, the adaptive response to antimicrobial host oxidants, the regulation of manganese and iron homeostasis, and the intricate regulatory networks that control the stress response. Here, we have also summarized less explored aspects such as the involvement of reparation systems and polyamine metabolism. A particular emphasis is put on the role of the oxidative stress response during the transient intracellular life of Streptococcus pneumoniae, including coinfection with influenza A and the induction of antibiotic persistence in host cells.
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spelling pubmed-105432772023-10-03 The oxidative stress response of Streptococcus pneumoniae: its contribution to both extracellular and intracellular survival Hernandez-Morfa, Mirelys Olivero, Nadia B. Zappia, Victoria E. Piñas, German E. Reinoso-Vizcaino, Nicolas M. Cian, Melina B. Nuñez-Fernandez, Mariana Cortes, Paulo R. Echenique, Jose Front Microbiol Microbiology Streptococcus pneumoniae is a gram-positive, aerotolerant bacterium that naturally colonizes the human nasopharynx, but also causes invasive infections and is a major cause of morbidity and mortality worldwide. This pathogen produces high levels of H(2)O(2) to eliminate other microorganisms that belong to the microbiota of the respiratory tract. However, it also induces an oxidative stress response to survive under this stressful condition. Furthermore, this self-defense mechanism is advantageous in tolerating oxidative stress imposed by the host’s immune response. This review provides a comprehensive overview of the strategies employed by the pneumococcus to survive oxidative stress. These strategies encompass the utilization of H(2)O(2) scavengers and thioredoxins, the adaptive response to antimicrobial host oxidants, the regulation of manganese and iron homeostasis, and the intricate regulatory networks that control the stress response. Here, we have also summarized less explored aspects such as the involvement of reparation systems and polyamine metabolism. A particular emphasis is put on the role of the oxidative stress response during the transient intracellular life of Streptococcus pneumoniae, including coinfection with influenza A and the induction of antibiotic persistence in host cells. Frontiers Media S.A. 2023-09-13 /pmc/articles/PMC10543277/ /pubmed/37789846 http://dx.doi.org/10.3389/fmicb.2023.1269843 Text en Copyright © 2023 Hernandez-Morfa, Olivero, Zappia, Piñas, Reinoso-Vizcaino, Cian, Nuñez-Fernandez, Cortes and Echenique. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Hernandez-Morfa, Mirelys
Olivero, Nadia B.
Zappia, Victoria E.
Piñas, German E.
Reinoso-Vizcaino, Nicolas M.
Cian, Melina B.
Nuñez-Fernandez, Mariana
Cortes, Paulo R.
Echenique, Jose
The oxidative stress response of Streptococcus pneumoniae: its contribution to both extracellular and intracellular survival
title The oxidative stress response of Streptococcus pneumoniae: its contribution to both extracellular and intracellular survival
title_full The oxidative stress response of Streptococcus pneumoniae: its contribution to both extracellular and intracellular survival
title_fullStr The oxidative stress response of Streptococcus pneumoniae: its contribution to both extracellular and intracellular survival
title_full_unstemmed The oxidative stress response of Streptococcus pneumoniae: its contribution to both extracellular and intracellular survival
title_short The oxidative stress response of Streptococcus pneumoniae: its contribution to both extracellular and intracellular survival
title_sort oxidative stress response of streptococcus pneumoniae: its contribution to both extracellular and intracellular survival
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543277/
https://www.ncbi.nlm.nih.gov/pubmed/37789846
http://dx.doi.org/10.3389/fmicb.2023.1269843
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