Allosteric Site Mediates Inhibition of Tonic NMDA Receptor Activity by Low Dose Ketamine

Ketamine, a general anesthetic, has rapid and sustained antidepressant effects when administered at lower doses. At anesthetic doses, ketamine causes a drastic reduction in excitatory transmission by lodging in the centrally located hydrophilic pore of the NMDA receptor, where it blocks ionic flow....

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Detalles Bibliográficos
Autores principales: Popescu, Gabriela, Abbott, Jamie, Wen, Han, Liu, Beiying, Gupta, Sheila, Iacobucci, Gary, Zheng, Wenjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543308/
https://www.ncbi.nlm.nih.gov/pubmed/37790558
http://dx.doi.org/10.21203/rs.3.rs-3304783/v1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543308/
https://www.ncbi.nlm.nih.gov/pubmed/37790558
http://dx.doi.org/10.21203/rs.3.rs-3304783/v1

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