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Allosteric Site Mediates Inhibition of Tonic NMDA Receptor Activity by Low Dose Ketamine
Ketamine, a general anesthetic, has rapid and sustained antidepressant effects when administered at lower doses. At anesthetic doses, ketamine causes a drastic reduction in excitatory transmission by lodging in the centrally located hydrophilic pore of the NMDA receptor, where it blocks ionic flow....
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Journal Experts
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543308/ https://www.ncbi.nlm.nih.gov/pubmed/37790558 http://dx.doi.org/10.21203/rs.3.rs-3304783/v1 |