Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway and generates TCF1+ progenitor CD8+ T cells to improve checkpoint blockade

TCF1(high) progenitor CD8+ T cells mediate the efficacy of PD-1 blockade, however the mechanisms that govern their generation and maintenance are poorly understood. Here, we show that targeting glycolysis through deletion of pyruvate kinase muscle 2 (PKM2) results in elevated pentose phosphate pathw...

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Detalles Bibliográficos
Autores principales: Markowitz, Geoffrey J., Ban, Yi, Tavarez, Diamile A., Yoffe, Liron, Podaza, Enrique, He, Yongfeng, Martin, Mitchell T., Crowley, Michael J. P., Sandoval, Tito A., Gao, Dingcheng, Martin, M. Laura, Elemento, Olivier, Cubillos-Ruiz, Juan R., McGraw, Timothy E., Altorki, Nasser K., Mittal, Vivek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543315/
https://www.ncbi.nlm.nih.gov/pubmed/37790365
http://dx.doi.org/10.21203/rs.3.rs-3356477/v1

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