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Bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against UV-induced skin damage

Excessive and prolonged ultraviolet radiation (UVR) exposure causes photodamage, photoaging, and photocarcinogenesis in human skin. Therefore, safe and effective sun protection is one of the most fundamental requirements. Living organisms tend to evolve various natural photoprotective mechanisms to...

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Autores principales: Zhang, Jia, Zhou, Yuqi, Jiang, Zhaoting, He, Chenhui, Wang, Bo, Wang, Qi, Wang, Zeqian, Wu, Tong, Chen, Xiaoqi, Deng, Ziwei, Li, Chunying, Jian, Zhe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543320/
https://www.ncbi.nlm.nih.gov/pubmed/37775761
http://dx.doi.org/10.1186/s12951-023-02107-7
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author Zhang, Jia
Zhou, Yuqi
Jiang, Zhaoting
He, Chenhui
Wang, Bo
Wang, Qi
Wang, Zeqian
Wu, Tong
Chen, Xiaoqi
Deng, Ziwei
Li, Chunying
Jian, Zhe
author_facet Zhang, Jia
Zhou, Yuqi
Jiang, Zhaoting
He, Chenhui
Wang, Bo
Wang, Qi
Wang, Zeqian
Wu, Tong
Chen, Xiaoqi
Deng, Ziwei
Li, Chunying
Jian, Zhe
author_sort Zhang, Jia
collection PubMed
description Excessive and prolonged ultraviolet radiation (UVR) exposure causes photodamage, photoaging, and photocarcinogenesis in human skin. Therefore, safe and effective sun protection is one of the most fundamental requirements. Living organisms tend to evolve various natural photoprotective mechanisms to avoid photodamage. Among them, melanin is the main functional component of the photoprotective system of human skin. Polydopamine (PDA) is synthesized as a mimic of natural melanin, however, its photoprotective efficiency and mechanism in protecting against skin damage and photoaging remain unclear. In this study, the novel sunscreen products based on melanin-inspired PDA nanoparticles (NPs) are rationally designed and prepared. We validate that PDA NPs sunscreen exhibits superior effects on photoprotection, which is achieved by the obstruction of epidermal hyperplasia, protection of the skin barrier, and resolution of inflammation. In addition, we find that PDA NPs are efficiently intake by keratinocytes, exhibiting robust ROS scavenging and DNA protection ability with minimal cytotoxicity. Intriguingly, PDA sunscreen has an influence on maintaining homeostasis of the dermis, displaying an anti-photoaging property. Taken together, the biocompatibility and full photoprotective properties of PDA sunscreen display superior performance to those of commercial sunscreen. This work provides new insights into the development of a melanin-mimicking material for sunscreens.
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spelling pubmed-105433202023-10-03 Bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against UV-induced skin damage Zhang, Jia Zhou, Yuqi Jiang, Zhaoting He, Chenhui Wang, Bo Wang, Qi Wang, Zeqian Wu, Tong Chen, Xiaoqi Deng, Ziwei Li, Chunying Jian, Zhe J Nanobiotechnology Research Excessive and prolonged ultraviolet radiation (UVR) exposure causes photodamage, photoaging, and photocarcinogenesis in human skin. Therefore, safe and effective sun protection is one of the most fundamental requirements. Living organisms tend to evolve various natural photoprotective mechanisms to avoid photodamage. Among them, melanin is the main functional component of the photoprotective system of human skin. Polydopamine (PDA) is synthesized as a mimic of natural melanin, however, its photoprotective efficiency and mechanism in protecting against skin damage and photoaging remain unclear. In this study, the novel sunscreen products based on melanin-inspired PDA nanoparticles (NPs) are rationally designed and prepared. We validate that PDA NPs sunscreen exhibits superior effects on photoprotection, which is achieved by the obstruction of epidermal hyperplasia, protection of the skin barrier, and resolution of inflammation. In addition, we find that PDA NPs are efficiently intake by keratinocytes, exhibiting robust ROS scavenging and DNA protection ability with minimal cytotoxicity. Intriguingly, PDA sunscreen has an influence on maintaining homeostasis of the dermis, displaying an anti-photoaging property. Taken together, the biocompatibility and full photoprotective properties of PDA sunscreen display superior performance to those of commercial sunscreen. This work provides new insights into the development of a melanin-mimicking material for sunscreens. BioMed Central 2023-09-30 /pmc/articles/PMC10543320/ /pubmed/37775761 http://dx.doi.org/10.1186/s12951-023-02107-7 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Zhang, Jia
Zhou, Yuqi
Jiang, Zhaoting
He, Chenhui
Wang, Bo
Wang, Qi
Wang, Zeqian
Wu, Tong
Chen, Xiaoqi
Deng, Ziwei
Li, Chunying
Jian, Zhe
Bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against UV-induced skin damage
title Bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against UV-induced skin damage
title_full Bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against UV-induced skin damage
title_fullStr Bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against UV-induced skin damage
title_full_unstemmed Bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against UV-induced skin damage
title_short Bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against UV-induced skin damage
title_sort bioinspired polydopamine nanoparticles as efficient antioxidative and anti-inflammatory enhancers against uv-induced skin damage
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543320/
https://www.ncbi.nlm.nih.gov/pubmed/37775761
http://dx.doi.org/10.1186/s12951-023-02107-7
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