Repurposing disulfiram, an alcohol-abuse drug, in neuroblastoma causes KAT2A downregulation and in vivo activity with a water/oil emulsion

Neuroblastoma, the most common type of pediatric extracranial solid tumor, causes 10% of childhood cancer deaths. Despite intensive multimodal treatment, the outcomes of high-risk neuroblastoma remain poor. We urgently need to develop new therapies with safe long-term toxicity profiles for rapid tes...

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Detalles Bibliográficos
Autores principales: Beaudry, Annie, Jacques-Ricard, Simon, Darracq, Anaïs, Sgarioto, Nicolas, Garcia, Araceli, García, Teresita Rode, Lemieux, William, Béland, Kathie, Haddad, Elie, Cordeiro, Paulo, Duval, Michel, McGraw, Serge, Richer, Chantal, Caron, Maxime, Marois, François, St-Onge, Pascal, Sinnett, Daniel, Banquy, Xavier, Raynal, Noël J.-M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543387/
https://www.ncbi.nlm.nih.gov/pubmed/37777587
http://dx.doi.org/10.1038/s41598-023-43219-2

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