Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity

We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune i...

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Autores principales: Moreno, Alberto, Manning, Kelly, Azeem, Maryam I., Nooka, Ajay K., Ellis, Madison, Manalo, Renee Julia, Switchenko, Jeffrey M., Wali, Bushra, Kaufman, Jonathan L., Hofmeister, Craig C., Joseph, Nisha S., Lonial, Sagar, Dhodapkar, Kavita M., Dhodapkar, Madhav V., Suthar, Mehul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543400/
https://www.ncbi.nlm.nih.gov/pubmed/37790523
http://dx.doi.org/10.21203/rs.3.rs-3293339/v1
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author Moreno, Alberto
Manning, Kelly
Azeem, Maryam I.
Nooka, Ajay K.
Ellis, Madison
Manalo, Renee Julia
Switchenko, Jeffrey M.
Wali, Bushra
Kaufman, Jonathan L.
Hofmeister, Craig C.
Joseph, Nisha S.
Lonial, Sagar
Dhodapkar, Kavita M.
Dhodapkar, Madhav V.
Suthar, Mehul S.
author_facet Moreno, Alberto
Manning, Kelly
Azeem, Maryam I.
Nooka, Ajay K.
Ellis, Madison
Manalo, Renee Julia
Switchenko, Jeffrey M.
Wali, Bushra
Kaufman, Jonathan L.
Hofmeister, Craig C.
Joseph, Nisha S.
Lonial, Sagar
Dhodapkar, Kavita M.
Dhodapkar, Madhav V.
Suthar, Mehul S.
author_sort Moreno, Alberto
collection PubMed
description We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.
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spelling pubmed-105434002023-10-03 Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity Moreno, Alberto Manning, Kelly Azeem, Maryam I. Nooka, Ajay K. Ellis, Madison Manalo, Renee Julia Switchenko, Jeffrey M. Wali, Bushra Kaufman, Jonathan L. Hofmeister, Craig C. Joseph, Nisha S. Lonial, Sagar Dhodapkar, Kavita M. Dhodapkar, Madhav V. Suthar, Mehul S. Res Sq Article We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity. American Journal Experts 2023-09-21 /pmc/articles/PMC10543400/ /pubmed/37790523 http://dx.doi.org/10.21203/rs.3.rs-3293339/v1 Text en https://creativecommons.org/licenses/by/4.0/This work is licensed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/) , which allows reusers to distribute, remix, adapt, and build upon the material in any medium or format, so long as attribution is given to the creator. The license allows for commercial use.
spellingShingle Article
Moreno, Alberto
Manning, Kelly
Azeem, Maryam I.
Nooka, Ajay K.
Ellis, Madison
Manalo, Renee Julia
Switchenko, Jeffrey M.
Wali, Bushra
Kaufman, Jonathan L.
Hofmeister, Craig C.
Joseph, Nisha S.
Lonial, Sagar
Dhodapkar, Kavita M.
Dhodapkar, Madhav V.
Suthar, Mehul S.
Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity
title Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity
title_full Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity
title_fullStr Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity
title_full_unstemmed Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity
title_short Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity
title_sort divergence of variant binding/neutralizing antibodies following sars-cov-2 booster vaccines in myeloma: impact of hybrid immunity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543400/
https://www.ncbi.nlm.nih.gov/pubmed/37790523
http://dx.doi.org/10.21203/rs.3.rs-3293339/v1
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