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Giant cells: multiple cells unite to survive

Multinucleated Giant Cells (MGCs) are specialized cells that develop from the fusion of multiple cells, and their presence is commonly observed in human cells during various infections. However, MGC formation is not restricted to infections alone but can also occur through different mechanisms, such...

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Autores principales: Hazra, Shreyasee, Kalyan Dinda, Suman, Kumar Mondal, Naba, Hossain, Sk Rajjack, Datta, Pratyay, Yasmin Mondal, Afsana, Malakar, Pushkar, Manna, Dipak
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543420/
https://www.ncbi.nlm.nih.gov/pubmed/37790914
http://dx.doi.org/10.3389/fcimb.2023.1220589
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author Hazra, Shreyasee
Kalyan Dinda, Suman
Kumar Mondal, Naba
Hossain, Sk Rajjack
Datta, Pratyay
Yasmin Mondal, Afsana
Malakar, Pushkar
Manna, Dipak
author_facet Hazra, Shreyasee
Kalyan Dinda, Suman
Kumar Mondal, Naba
Hossain, Sk Rajjack
Datta, Pratyay
Yasmin Mondal, Afsana
Malakar, Pushkar
Manna, Dipak
author_sort Hazra, Shreyasee
collection PubMed
description Multinucleated Giant Cells (MGCs) are specialized cells that develop from the fusion of multiple cells, and their presence is commonly observed in human cells during various infections. However, MGC formation is not restricted to infections alone but can also occur through different mechanisms, such as endoreplication and abortive cell cycle. These processes lead to the formation of polyploid cells, eventually resulting in the formation of MGCs. In Entamoeba, a protozoan parasite that causes amoebic dysentery and liver abscesses in humans, the formation of MGCs is a unique phenomenon and not been reported in any other protozoa. This organism is exposed to various hostile environmental conditions, including changes in temperature, pH, and nutrient availability, which can lead to stress and damage to its cells. The formation of MGCs in Entamoeba is thought to be a survival strategy to cope with these adverse conditions. This organism forms MGCs through cell aggregation and fusion in response to osmotic and heat stress. The MGCs in Entamoeba are thought to have increased resistance to various stresses and can survive longer than normal cells under adverse conditions. This increased survival could be due to the presence of multiple nuclei, which could provide redundancy in case of DNA damage or mutations. Additionally, MGCs may play a role in the virulence of Entamoeba as they are found in the inflammatory foci of amoebic liver abscesses and other infections caused by Entamoeba. The presence of MGCs in these infections suggests that they may contribute to the pathogenesis of the disease. Overall, this article offers valuable insights into the intriguing phenomenon of MGC formation in Entamoeba. By unraveling the mechanisms behind this process and examining its implications, researchers can gain a deeper understanding of the complex biology of Entamoeba and potentially identify new targets for therapeutic interventions. The study of MGCs in Entamoeba serves as a gateway to exploring the broader field of cell fusion in various organisms, providing a foundation for future investigations into related cellular processes and their significance in health and disease.
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spelling pubmed-105434202023-10-03 Giant cells: multiple cells unite to survive Hazra, Shreyasee Kalyan Dinda, Suman Kumar Mondal, Naba Hossain, Sk Rajjack Datta, Pratyay Yasmin Mondal, Afsana Malakar, Pushkar Manna, Dipak Front Cell Infect Microbiol Cellular and Infection Microbiology Multinucleated Giant Cells (MGCs) are specialized cells that develop from the fusion of multiple cells, and their presence is commonly observed in human cells during various infections. However, MGC formation is not restricted to infections alone but can also occur through different mechanisms, such as endoreplication and abortive cell cycle. These processes lead to the formation of polyploid cells, eventually resulting in the formation of MGCs. In Entamoeba, a protozoan parasite that causes amoebic dysentery and liver abscesses in humans, the formation of MGCs is a unique phenomenon and not been reported in any other protozoa. This organism is exposed to various hostile environmental conditions, including changes in temperature, pH, and nutrient availability, which can lead to stress and damage to its cells. The formation of MGCs in Entamoeba is thought to be a survival strategy to cope with these adverse conditions. This organism forms MGCs through cell aggregation and fusion in response to osmotic and heat stress. The MGCs in Entamoeba are thought to have increased resistance to various stresses and can survive longer than normal cells under adverse conditions. This increased survival could be due to the presence of multiple nuclei, which could provide redundancy in case of DNA damage or mutations. Additionally, MGCs may play a role in the virulence of Entamoeba as they are found in the inflammatory foci of amoebic liver abscesses and other infections caused by Entamoeba. The presence of MGCs in these infections suggests that they may contribute to the pathogenesis of the disease. Overall, this article offers valuable insights into the intriguing phenomenon of MGC formation in Entamoeba. By unraveling the mechanisms behind this process and examining its implications, researchers can gain a deeper understanding of the complex biology of Entamoeba and potentially identify new targets for therapeutic interventions. The study of MGCs in Entamoeba serves as a gateway to exploring the broader field of cell fusion in various organisms, providing a foundation for future investigations into related cellular processes and their significance in health and disease. Frontiers Media S.A. 2023-09-05 /pmc/articles/PMC10543420/ /pubmed/37790914 http://dx.doi.org/10.3389/fcimb.2023.1220589 Text en Copyright © 2023 Hazra, Kalyan Dinda, Kumar Mondal, Hossain, Datta, Yasmin Mondal, Malakar and Manna https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Hazra, Shreyasee
Kalyan Dinda, Suman
Kumar Mondal, Naba
Hossain, Sk Rajjack
Datta, Pratyay
Yasmin Mondal, Afsana
Malakar, Pushkar
Manna, Dipak
Giant cells: multiple cells unite to survive
title Giant cells: multiple cells unite to survive
title_full Giant cells: multiple cells unite to survive
title_fullStr Giant cells: multiple cells unite to survive
title_full_unstemmed Giant cells: multiple cells unite to survive
title_short Giant cells: multiple cells unite to survive
title_sort giant cells: multiple cells unite to survive
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543420/
https://www.ncbi.nlm.nih.gov/pubmed/37790914
http://dx.doi.org/10.3389/fcimb.2023.1220589
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