The PALB2 DNA-binding domain is an intrinsically disordered recombinase

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The Partner and Localizer of BRCA2 (PALB2) tumor suppressor is a scaffold protein that links BRCA1 with BRCA2 to initiate homologous recombination (HR). PALB2 interaction with DNA strongly enhances HR efficiency. The PALB2 DNA-binding domain (PALB2-DBD) supports DNA strand exchange, a complex multis...

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Detalles Bibliográficos
Autores principales: Kyriukha, Yevhenii, Watkins, Maxwell B., Redington, Jennifer M., Dastvan, Reza, Uversky, Vladimir N., Hopkins, Jesse, Pozzi, Nicola, Korolev, Sergey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543426/
https://www.ncbi.nlm.nih.gov/pubmed/37790553
http://dx.doi.org/10.21203/rs.3.rs-3235465/v1
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