Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Bivalent molecules consisting of groups connected through bridging linkers often exhibit strong target binding and unique biological effects. However, developing bivalent inhibitors with the desired activity is challenging due to the dual motif architecture of these molecules and the variability tha...

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Detalles Bibliográficos
Autores principales: Heppner, David, Wittlinger, Florian, Ogboo, Blessing, Shevchenko, Ekaterina, Damghani, Tahereh, Pham, Calvin, Schaeffner, Ilse, Oligny, Brandon, Chitnis, Surbhi, Beyett, Tyler, Rasch, Alexander, Buckley, Brian, Urul, Daniel, Shaurova, Tatiana, May, Earl, Schaefer, Erik, Eck, Michael, Hershberger, Pamela, Poso, Antti, Laufer, Stefan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10543509/
https://www.ncbi.nlm.nih.gov/pubmed/37790373
http://dx.doi.org/10.21203/rs.3.rs-3286949/v1

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